{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:22:26Z","timestamp":1791818546130,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Review of the literature with critical appraisal and clinical recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To highlight contemporary concepts involving adjunctive medical and non-surgical therapies in the management of acute traumatic spinal cord injury (tSCI) that may be integrated into clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three recent articles relating to the management of acute tSCI were selected and critically appraised. Clinical practice recommendations were developed and evaluated using the GRADE criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Article 1: A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on Hemodynamic Management.\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">Conditional recommendation<\/jats:italic>\n                      <\/jats:bold>\n                      to augment mean arterial blood pressure to at least 75-80\u00a0mmHg but not higher than 90-95\u00a0mmHg for a duration of 3-7 days to optimize spinal cord perfusion in acute tSCI. Article 2: Spinal Cord Perfusion Pressure Predicts Neurologic Recovery in Acute Spinal Cord Injury.\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">No recommendation<\/jats:italic>\n                      <\/jats:bold>\n                      can be made at this time in the utilization of SCPP-guided hemodynamic management as an adjunctive strategy in the acute care of tSCI. Article 3: Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS).\n                      <jats:bold>\n                        <jats:italic toggle=\"yes\">No recommendation<\/jats:italic>\n                      <\/jats:bold>\n                      can currently be made on the routine use of riluzole to patients with acute cervical tSCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The management of tSCI extends beyond the operating room. The development of emerging medical and non-surgical treatments to augment timely and adequate decompression requires critical consideration as new data becomes available. While some topics do not have the scientific backing to be able to make a recommendation at this time, they point towards areas of future study.<\/jats:p>\n                    <jats:p>\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"10.1177_21925682261423534-img1.png\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682261423534","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:40:21Z","timestamp":1771335621000},"page":"1700-1706","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["AO Spine Clinical Practice Recommendations for Adjunctive Medical Therapies in Acute Traumatic Spinal Cord Injury: Contemporary Concepts"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-6454","authenticated-orcid":false,"given":"Chris J.","family":"Neal","sequence":"first","affiliation":[{"name":"Maine Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Rodrigues-Pinto","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio"},{"name":"University of Porto"},{"name":"Hospital CUF Trindade"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Grassner","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University Salzburg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-5818","authenticated-orcid":false,"given":"Vanessa","family":"Hubertus","sequence":"additional","affiliation":[{"name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin and Berlin Institute of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-9034","authenticated-orcid":false,"given":"Farzin","family":"Farahbakhsh","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jetan H.","family":"Badhiwala","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The University of Sydney"},{"name":"The University of Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Hejrati","sequence":"additional","affiliation":[{"name":"HOCH Health Ostschweiz"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-7695","authenticated-orcid":false,"given":"Paul","family":"Arnold","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-6364","authenticated-orcid":false,"given":"Michael G.","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery and Spine Program University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Kwon","sequence":"additional","affiliation":[{"name":"The International Collaboration on Repair Discoveries (ICORD) University of British Columbia"},{"name":"Vancouver Spine Surgery Institute"},{"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Vancouver Spine Surgery Institute"},{"name":"University of British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Shekar Kurpad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032037"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540440031029"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002517-200006000-00001"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws072"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2008.0745"},{"key":"e_1_3_4_7_2","first-page":"407","article-title":"Guidelines for the management of acute cervical spine and spinal cord injuries","volume":"49","author":"Hadley MN","year":"2002","unstructured":"Hadley MN, Walters BC, Grabb PA, et al. 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