{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:42:43Z","timestamp":1792258963787,"version":"4.4.0"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Spine Journal"],"abstract":"<jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between androgen deprivation therapy (ADT), vertebral compression fracture (VCF) incidence, and subsequent vertebral augmentation (vertebroplasty\/kyphoplasty) utilization in adult men with prostate cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult men with prostate cancer were stratified by ADT exposure and matched 1:1 to non-ADT controls on demographics, comorbidities, and bone health. Primary outcomes were VCF incidence at 3 months, 1 year, 3 years, and 5 years and vertebral augmentation utilization. Secondary outcomes included posterior spinal instrumentation, dependency, fracture burden, and bisphosphonate\/denosumab use. Risks were compared using Kaplan-Meier and Cox proportional hazards models, with chi-square tests for categorical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After matching, 122,511 patients were included per cohort. ADT was associated with higher 5-year VCF incidence (1.95% vs 1.29%; HR, 1.49; p &lt; 0.001), representing a 54% relative increase (NNH = 143), with consistent findings at earlier time points (all p &lt; 0.05). Among 2,926 matched pairs with VCFs, vertebral augmentation utilization was higher with ADT (7.4% vs 5.1%; p &lt; 0.001), representing a 45% relative increase. Posterior instrumentation (2.1% vs 2.0%) and dependency (7.5% vs 7.7%) were similar, while fracture burden did not differ (p = 0.07).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ADT is associated with increased VCF incidence and vertebral augmentation utilization without differences in posterior instrumentation. This pattern is consistent with osteoporotic insufficiency fractures and supports bone health screening and preventive therapy at ADT initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/21925682261496842","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:23:37Z","timestamp":1791915817000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fracture and Vertebral Augmentation Utilization Following Androgen Deprivation Therapy in Men With Prostate Cancer: A Propensity Score\u2013matched Cohort Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2553-3017","authenticated-orcid":false,"given":"Taha","family":"Taka","sequence":"first","affiliation":[{"name":"Loma Linda University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1539-0964","authenticated-orcid":false,"given":"Carson","family":"Cummings","sequence":"additional","affiliation":[{"name":"Loma Linda University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2587-4706","authenticated-orcid":false,"given":"Sarah","family":"Meng","sequence":"additional","affiliation":[{"name":"Loma Linda University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Miner","sequence":"additional","affiliation":[{"name":"University of California \u2013 Riverside"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4820-7927","authenticated-orcid":false,"given":"Graydon","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Loma Linda University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shin","sequence":"additional","affiliation":[{"name":"Loma Linda University Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trupti","family":"Trivedi","sequence":"additional","affiliation":[{"name":"Duke University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-2751","authenticated-orcid":false,"given":"Rory","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Duke University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Richardson","sequence":"additional","affiliation":[{"name":"Duke University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olumide","family":"Danisa","sequence":"additional","affiliation":[{"name":"Duke University Health System"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.0228"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2006.tb00180.x"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01696"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.10.006"},{"key":"e_1_3_4_6_2","first-page":"225","article-title":"American Cancer Society prostate cancer survivorship care guidelines","volume":"64","author":"Skolarus TA","unstructured":"Skolarus TA, Wolf AMD, Erb NL, et al. 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