{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:49:56Z","timestamp":1789516196422,"version":"build-2803163510"},"reference-count":62,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Cardiopulmonary exercise testing (CPET) is the gold-standard for quantification of peak oxygen uptake (VO\n                      <jats:sub>2<\/jats:sub>\n                      ) and cardiorespiratory and muscle responses to exercise. Its application to Duchenne muscular dystrophy (DMD) has been scarce due to the notion that muscle weakness inherent to disease restricts the cardiorespiratory system from reaching maximal capacity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To investigate the utility of CPET in DMD by 1) establishing whether patients can perform maximal-effort exercise for valid VO\n                      <jats:sub>2<\/jats:sub>\n                      peak assessment; 2) quantifying VO\n                      <jats:sub>2<\/jats:sub>\n                      peak repeatability; 3) characterizing muscle and cardiorespiratory responses; 4) comparing VO\n                      <jats:sub>2<\/jats:sub>\n                      peak to 6-min walk distance (6MWD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Twenty-seven DMD and eight healthy boys (6 years and older) underwent CPET using an incremental work-rate protocol for leg (ambulatory) or arm (non-ambulatory) cycling with measurement of heart rate (HR) and gas-exchange variables from rest to maximal-effort. The oxygen cost of work (\u0394VO\n                      <jats:sub>2<\/jats:sub>\n                      \/\u0394work-rate) was calculated, and peak exercise parameters (VO\n                      <jats:sub>2<\/jats:sub>\n                      , HR, O\n                      <jats:sub>2<\/jats:sub>\n                      pulse, ventilation (VE) and ventilatory threshold (VT)) were considered valid if the respiratory exchange ratio \u22651.01.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      VO\n                      <jats:sub>2<\/jats:sub>\n                      peak was valid (81.5% of patients), repeatable (intraclass correlation coefficient\u2009=\u20090.998) and low in ambulatory and non-ambulatory DMD compared to controls (19.0\u2009\u00b1\u20096.0; 10.7\u2009\u00b1\u20092; 35.2\u2009\u00b1\u20094.5\u2005mL\/kg\/min respectively). VT was low (30.8\u2009\u00b1\u200910.7; 19.4\u2009\u00b1\u20093.0; 61.2\u2009\u00b1\u20096.9% VO\n                      <jats:sub>2<\/jats:sub>\n                      peak) reflecting significant muscle metabolic impairment. Peak HR in ambulatory-DMD (172\u2009\u00b1\u200914\u2005bpm) was similar to controls (183\u2009\u00b1\u20098.3\u2005bpm), but O\n                      <jats:sub>2<\/jats:sub>\n                      pulse was low (3.4\u2009\u00b1\u20091.0; 6.5\u2009\u00b1\u20091.1\u2005mL\/beat). Peak VE\/VO\n                      <jats:sub>2<\/jats:sub>\n                      (ambulatory\u2009=\u200942.1\u2009\u00b1\u20096.8; non-ambulatory\u2009=\u200942.2\u2009\u00b1\u20097.8; controls\u2009=\u200934.3\u2009\u00b1\u20094.6) and \u0394VO\n                      <jats:sub>2<\/jats:sub>\n                      \/\u0394work-rate were elevated (ambulatory\u2009=\u200912.4\u2009\u00b1\u20094.9; non-ambulatory\u2009=\u200919.0\u2009\u00b1\u20099.7; controls\u2009=\u200910.1\u2009\u00b1\u20090.8) revealing ventilatory and mechanical inefficiency. Despite strong correlation between VO\n                      <jats:sub>2<\/jats:sub>\n                      peak and 6MWD, severity of impairment was discordant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Valid CPET is feasible in DMD, revealing low VO\n                      <jats:sub>2<\/jats:sub>\n                      peak due to abnormal muscle metabolic and cardiorespiratory responses during dynamic exercise. CPET reveals cardiorespiratory limitations in DMD boys with unremarkable 6MWD, and should be considered an integrative approach in clinical care and assessment of emerging therapeutics.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22143602251319170","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T14:11:40Z","timestamp":1741097500000},"page":"408-423","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cardiopulmonary exercise testing as an integrative approach to explore physiological limitations in Duchenne muscular dystrophy"],"prefix":"10.1177","volume":"12","author":[{"given":"Meghana","family":"Bomma","sequence":"first","affiliation":[{"name":"Department of Physiology and Aging, University of Florida, Gainesville, FL, 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