{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:44:00Z","timestamp":1753883040011,"version":"3.41.2"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"abstract":"<jats:p>We report an exceptional case of immune-mediated necrotizing myopathy (IMNM) associated with anaplastic large cell lymphoma (ALCL). A 26-year-old female patient presented with subacute bilateral proximal muscle weakness and myalgia, highly elevated creatin kinase (CK), and seropositivity for anti-SRP antibodies. Tumor screening by FDG-PET\/CT detected an enlarged axillary lymph node with high FDG uptake. Histology of the excised lymph node revealed ALCL, positive for ALK and CD30. Therapy with brentuximab, cyclophosphamide and doxorubicin resulted in complete remission of the lymphoma, additional treatment with oral steroids and repeated cycles of intravenous immunoglobulins led to improvement of muscle weakness and normalization of CK. 18 months after diagnosis the patient remains tumor free with mild to moderate residual axial weakness. A literature review of paraneoplastic anti-SRP antibody positive IMNM identified eleven cases of whom five had a tumor diagnosis within a \u00b13 years window. The majority of patients had different solid tumors except one with a hematological malignancy. Despite the rare association of anti-SRP antibody positive IMNM and malignancy, early extensive tumor screening was crucial for the management of our patient.<\/jats:p>","DOI":"10.1177\/22143602251327002","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:51:34Z","timestamp":1745423494000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Paraneoplastic anti-SRP antibody positive immune-mediated necrotizing myopathy in a young female associated with lymphoma."],"prefix":"10.1177","author":[{"given":"Johanna","family":"Heugenhauser","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska Di","family":"Pauli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Stockhammer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Chott","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Klinik Ottakring, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Feistritzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, Hematology and Oncology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Egle","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Breast Cancer Center Tirol, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Henninger","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Wanschitz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42345"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00321-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0120-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww054"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac144"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42311"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00515-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.12.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.09.016"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01045-w"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.01.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000290"},{"key":"e_1_3_3_14_2","volume-title":"Diagnosing and treating adult cancers and associated impairments","author":"National Academies of Sciences EaM, Health and Medicine D, Board on Health Care S, Committee on Diagnosing and Treating Adult C","year":"2021","unstructured":"National Academies of Sciences EaM, Health and Medicine D, Board on Health Care S, Committee on Diagnosing and Treating Adult C. Diagnosing and treating adult cancers and associated impairments. Washington, DC: National Academies Press (US) Copyright 2021 by the National Academy of Sciences. All Rights Reserved, 2021."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac115"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-99716-2_6"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509051721"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.cn-000982"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2021-003073"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.08.060"},{"key":"e_1_3_3_21_2","first-page":"557","article-title":"Paraneoplastic necrotizing myopathy presenting as severe muscle weakness in a patient with small-cell lung cancer: successful response to chemoradiation therapy","volume":"9","author":"Vu HJ","year":"2011","unstructured":"Vu HJ, Pham D, Makary R, et al. Paraneoplastic necrotizing myopathy presenting as severe muscle weakness in a patient with small-cell lung cancer: successful response to chemoradiation therapy. Clin Adv Hematol Oncol 2011; 9: 557\u2013556.","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2023.101444"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04417.x"}],"container-title":["Journal of Neuromuscular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22143602251327002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22143602251327002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22143602251327002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:51:35Z","timestamp":1745423495000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22143602251327002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":22,"alternative-id":["10.1177\/22143602251327002"],"URL":"https:\/\/doi.org\/10.1177\/22143602251327002","relation":{},"ISSN":["2214-3599","2214-3602"],"issn-type":[{"type":"print","value":"2214-3599"},{"type":"electronic","value":"2214-3602"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"article-number":"22143602251327002"}}