{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:52:15Z","timestamp":1790117535153,"version":"4.0.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>In patients with Duchenne muscular dystrophy (DMD) the effect of continued corticosteroid (CS) use into adulthood on respiratory function remains unclear. We studied if prolongation of CS into adulthood is beneficial for forced vital capacity (FVC), age at start of non-invasive ventilation (NIV), and age at start of continuous (24\/24\u2005h) ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this retrospective study, adult (\u226518 years) DMD patients were stratified into 20 \u2018CS-na\u00efve\u2019 patients (never used CS or only as a child during &lt;1 year) and 37 \u2018continued CS\u2019 patients (continued CS until age of 18 years or older).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\u2018Continued CS\u2019 patients showed at 18 years a higher FVC%pred (50.3, SD:16.4) compared to \u2018CS-na\u00efve\u2019 patients (36.9, SD:13.8) (p\u2009=\u20090.007). Patients continuing CS beyond the age of 18 demonstrated a slower annual decline in FVC%pred of 2.9% (SE:0.5) in comparison to 3.8% (SE:0.4) in the \u2018CS-na\u00efve\u2019 group, and the difference in relative annual decline in FVC%pred was significant (p\u2009=\u20090.012). The annual decline in FVC in absolute value in patients continuing CS was 102\u2005ml (SE:28) slower in comparison to \u2018CS-na\u00efve\u2019 patients (p\u2009&lt;\u20090.001). Moreover, there was a delay in age at initiation of NIV: mean age at start of NIV was 28.3 (95%CI: 25.4\u201331.2) in \u2018continued CS\u2019 in comparison to 20.3 (95%CI: 19.0\u201321.6) in \u2018CS-na\u00efve\u2019 patients (p\u2009&lt;\u20090.001), and at start of continuous NIV 33.3 (95%CI: 31.5\u201335.2) in comparison to 26.0 (95%CI: 24.7\u201327.2) years (p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our data suggest benefit of continuing CS until age 18 years and beyond on respiratory function including delayed need to start (continuous) NIV.<\/jats:p>\n                  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