{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:31:25Z","timestamp":1793266285990,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["Orphan Products Grant R01FD006649"],"award-info":[{"award-number":["Orphan Products Grant R01FD006649"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["Grant UL1 RR024975-01"],"award-info":[{"award-number":["Grant UL1 RR024975-01"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fighting Duchenne Foundation and the Fight DMD","award":["Jonah & Emory Discovery Grant"],"award-info":[{"award-number":["Jonah & Emory Discovery Grant"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["Grant 2 UL1 TR000445-06"],"award-info":[{"award-number":["Grant 2 UL1 TR000445-06"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL123938"],"award-info":[{"award-number":["K23HL123938"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL167969"],"award-info":[{"award-number":["R01HL167969"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R56HL141248"],"award-info":[{"award-number":["R56HL141248"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Duchenne muscular dystrophy (DMD) is marked by cardiac and skeletal myopathy with disparate onset and progression suggesting distinct pathophysiologies. Nontargeted proteomics may elucidate the different disease pathways underlying skeletal muscle and cardiomyopathy progression and identify proteins that improve DMD risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Sixty subjects were enrolled; 56 underwent cardiac magnetic resonance to determine left ventricular ejection fraction, late gadolinium enhancement, and myocardial circumferential strain. Of the 60 patients enrolled, 51 underwent quantitative muscle testing and 33 underwent actigraphy. Aptamer-based technology (SomaScan) evaluated 1128 proteins in plasma. The correlations between serum protein levels and cardiac or skeletal muscle indices were tested using a Spearman correlation test followed by multiple testing correction yielding\n                      <jats:italic toggle=\"yes\">q<\/jats:italic>\n                      -values. The median age was 15.0 years (12.7\u201317.9 interquartile range). Of 1128 proteins analyzed, 208 correlated with only cardiac indices; 14 correlated with only skeletal muscle indices; 10 proteins correlated strongly with both indices. Protein functions included (1) calcium regulation, (2) cardiac remodeling, (3) cell homeostasis, (4) fibrosis, (5) inflammation, (6) lipid regulation, and (7) other.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our nontargeted proteomics study identified serum biomarkers correlating with skeletal and cardiac progression in DMD. Candidate proteins\u2014some uniquely associated with skeletal or cardiac indices and others overlapping\u2014offer promising leads for studies to improve risk stratification and guide targeted therapies in DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22143602261438533","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:50:27Z","timestamp":1776261027000},"page":"1350-1360","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of novel protein biomarkers correlating with both cardiac and skeletal muscle indices in duchenne muscular dystrophy"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7403-7731","authenticated-orcid":false,"given":"Mark","family":"Naguib","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katheryn E","family":"Gambetta","sequence":"additional","affiliation":[{"name":"Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn","family":"Tamaroff","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B","family":"Burnette","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4287-3658","authenticated-orcid":false,"given":"Rachel","family":"Harris","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[{"name":"Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Slaughter","sequence":"additional","affiliation":[{"name":"Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Markham","sequence":"additional","affiliation":[{"name":"Indiana University Health, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Spurney","sequence":"additional","affiliation":[{"name":"Children's National Hospital, Washington, D.C., USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H","family":"Soslow","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the DMDCCC","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0009922809347777"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90579-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-8994(95)00251-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(90)90082-G"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-020-02309-y"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032960"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-001-0040-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-017-1703-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.02.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-016-0224-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0963-x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000076"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1067\/mnc.2002.123122"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-014-0929-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00736-1"},{"key":"e_1_3_3_18_2","article-title":"Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy","volume":"13","author":"Barnard AM","year":"2018","unstructured":"Barnard AM, Willcocks RJ, Finanger EL, et al. 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