{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:22:28Z","timestamp":1777789348971,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>A neurodegenerative disorder, glaucoma is a leading cause of blindness in the world. The conventional treatment strategies do not allow the significant penetration of the drug in the cornea. Therefore, we prepare a brinzolamide (Brz) loaded core-shell nanoparticles (NPs) to enhance the coronial penetration of the drug and thus treating the glaucoma. The shell of the NPs was composed of phosphatidylserine (PS; 1,2-diacyl-sn-glycero-3-phospho-L-serine), whereas the core of the NPs contains the Brz encapsulated in brinzolamide\u2013phosphatidylserine\u2013polymer poly-(DL-lactic acid-co-glycolic acid)\u2013phosphatidylserine (Brz-PS-PLGA). The synthesis of Brz-PS-PLGA was achieved by using a coaxial electrospray process (CEP), which allows the preparation of the particles in a single step. The size of Brz-PS-PLGA with PS shell and brinzolamide\u2013poly (lactic-co-glycolic) acid (Brz-PLGA) without shell was 571 \u00b1 27.02 nm and 456 \u00b1 19.17 nm, respectively. The charges on the surface of Brz-PS-PLGA and Brz-PLGA were (-) 27.45 \u00b1 2.98 mV and (-) 19.47 \u00b1 2.83 mV. The transmission electron microscopy images clearly reveal the PS shell as a light black layer over the dark black PLGA core. The CEP allows the high encapsulation of Brz in Brz-PS-PLGA where percentage of entrapment efficiency for Brz-PS-PLGA was 88.13 \u00b1 6.43%. The release study conducted in a simulated tear fluid revealed the sustained release patterns of Brz from Brz-PS-PLGA and these were nontoxic to the cells as revealed by the cytotoxicity studies. Further, the Brz-PS-PLGA enhanced the coronial penetration of Brz and was capable of significantly reducing the intraocular pressure (IOP) after administration to the rabbit eye in comparison to the Brz-PLGA and free Brz. The results clearly suggest that the PS coating significantly enhances the capability of the particles in reducing IOP.<\/jats:p>","DOI":"10.1177\/2280800020942712","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T20:57:00Z","timestamp":1604696220000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Brinzolamide loaded core-shell nanoparticles for enhanced coronial penetration in the treatment of glaucoma"],"prefix":"10.1177","volume":"18","author":[{"given":"Jing","family":"Song","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First People\u2019s Hospital of Lianyungang, Lianyungang, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-4771","authenticated-orcid":false,"given":"Ziping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First People\u2019s Hospital of Lianyungang, Lianyungang, Jiangsu, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"issue":"1","key":"bibr1-2280800020942712","first-page":"73","volume":"89","author":"Gauthier AC","year":"2016","journal-title":"Yale J Biol Med"},{"key":"bibr2-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00931"},{"key":"bibr3-2280800020942712","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1130_17"},{"key":"bibr4-2280800020942712","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200320120-00008"},{"key":"bibr5-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1038\/srep44229"},{"key":"bibr6-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1731861"},{"issue":"3","key":"bibr7-2280800020942712","first-page":"390","volume":"6","author":"Zhou H-Y","year":"2013","journal-title":"Int J Ophthalmol"},{"key":"bibr8-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-010-9183-3"},{"key":"bibr9-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"bibr10-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA09928J"},{"key":"bibr11-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3390\/nano10020355"},{"key":"bibr12-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3390\/s110201744"},{"key":"bibr13-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00214-z"},{"key":"bibr14-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks286"},{"key":"bibr15-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2019.04.048"},{"key":"bibr16-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2017.1367006"},{"key":"bibr17-2280800020942712","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200218101231"},{"key":"bibr18-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.109950"},{"key":"bibr19-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.10.220"},{"key":"bibr20-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2014.965324"},{"key":"bibr21-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119368"},{"key":"bibr22-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3390\/ma12203323"},{"key":"bibr23-2280800020942712","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020057"},{"key":"bibr24-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2014.08.061"},{"key":"bibr25-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00862"},{"key":"bibr26-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1586\/erd.12.58"},{"key":"bibr27-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.03.009"},{"key":"bibr28-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067595"},{"key":"bibr29-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-008-0391-z"},{"key":"bibr30-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2007.09.082"},{"key":"bibr31-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0298-153"},{"key":"bibr32-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1063\/1.1850691"},{"key":"bibr33-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC09131A"},{"key":"bibr34-2280800020942712","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-017-0710-8"}],"container-title":["Journal of Applied Biomaterials &amp; 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