{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:23:21Z","timestamp":1777789401789,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Dentin hypersensitivity (DH) is a common oral disease with approximately 41.9% prevalence. Reconstruction of dental hard tissues is the preferred treatment for relieving DH. Here, we applied biomineralization method using oligopeptide simulating cementum protein 1 (CEMP1) to regenerate hard tissues on demineralized dentin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The self-assembly and biomineralization property of the oligopeptide were detected by scanning electron microscopy (SEM), circular dichroism spectroscopy, and transmission electron microscopy. Oligopeptide\u2019s binding capacity to demineralized dentin was evaluated by SEM and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Remineralization was characterized using SEM, ATR-FTIR, X-ray diffraction, and nanoindentation. Oligopeptide\u2019s biocompatibility was evaluated using periodontal ligament cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Oligopeptides self-assembled into nano-matrix and templated mineral precursor formation within 24\u2009h. Moreover, oligopeptide nano-matrix bound firmly on demineralized dentin and resisted water rinsing. Then, bound nano-matrix served as a template to initiate nucleation and transformation of hydroxyapatite on demineralized dentin. After 96\u2009h, oligopeptide nano-matrix regenerated an enamel-like tissue layer with a thickness of 15.35\u2009\u03bcm, and regenerated crystals occluded dentin tubules with a depth of 31.27\u2009\u03bcm. Furthermore, the oligopeptide nano-matrix had good biocompatibility when co-cultured with periodontal ligament cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This biomimetic oligopeptide simulating CEMP1 effectively induced remineralization and reconstructed hard tissues on demineralized dentin, providing a potential biomaterial for DH treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22808000211005384","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T13:35:55Z","timestamp":1617111355000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Biomimetic oligopeptide formed enamel-like tissue and dentin tubule occlusion via mineralization for dentin hypersensitivity treatment"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-9481","authenticated-orcid":false,"given":"Qing-qing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 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