{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:26:06Z","timestamp":1777789566663,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"consejo nacional de ciencia y tecnolog\u00eda","doi-asserted-by":"publisher","award":["Sectorial Fund for Education Research grant A1-S-2"],"award-info":[{"award-number":["Sectorial Fund for Education Research grant A1-S-2"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the antitumor and antimicrobial properties of an alginate-based membrane (ABM) loaded with bismuth lipophilic nanoparticles (BisBAL NPs) and cetylpyridinium chloride (CPC) on clinically isolated bacteria and a pancreatic cancer cell line.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods:<\/jats:title>\n                    <jats:p>The BisBAL NP-CPC ABM was characterized using optical and scanning electron microscopy (SEM). The antimicrobial potential was measured using the disk-diffusion assay, and antibiofilm activity was determined through the live\/dead assay and fluorescence microscopy. The antitumor activity was analyzed on the pancreatic cell line (Panc 03.27) using the MTT assay and live\/dead assay with fluorescence microscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After a 24-h exposure (37\u00b0C, aerobic conditions), 5\u2009\u00b5M BisBAL NP reduced the growth of K. pneumoniae by 77.9%, while 2.5\u2009\u00b5M BisBAL NP inhibited the growth of Salmonella, E. faecalis and E. faecium by 82.9%, 82.6%, and 78%, respectively ( p\u2009&lt;\u20090.0001). The BisBAL NPs-CPC ABM (at a ratio of 10:1; 500 and 50\u2009\u00b5M, respectively) inhibited the growth of all isolated bacteria, producing inhibition halos of 9.5, 11.2, 7, and 10.3\u2009mm for K. pneumoniae, Salmonella, E. faecalis, and E. faecium, respectively, in contrast to the 6.5, 9.5, 8.5, and 9.8\u2009mm obtained with 100\u2009\u00b5M ceftriaxone ( p\u2009&lt;\u20090.0001). The BisBAL NPs-CPC ABM also reduced bacterial biofilms, with 81.4%, 74.5%, 97.1%, and 79.5% inhibition for K. pneumoniae, E. faecium, E. faecalis, and Salmonella, respectively. Furthermore, the BisBAL NPs-CPC ABM decreased Panc 03.27 cell growth by 76%, compared to 18% for drug-free ABM. GEM-ABM reduced tumoral growth by 73%. The live\/dead assay confirmed that BisBAL NPs-CPC-ABM and GEM-ABM were cytotoxic for the turmoral Panc 03.27 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An alginate-based membrane loaded with BisBAL NP and CPC exhibits dual antimicrobial and antitumoral efficacy. Therefore, it could be applied in cancer treatment and to diminish the occurrence of surgical site infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22808000241236590","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T01:24:00Z","timestamp":1709688240000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial and antitumor activities of an alginate-based membrane loaded with bismuth nanoparticles and cetylpyridinium chloride"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-0111","authenticated-orcid":false,"given":"Claudio","family":"Cabral-Romero","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Hern\u00e1ndez-Delgadillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Eduardo","family":"Nakagoshi-Cepeda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Isela","family":"S\u00e1nchez-Naj\u00e9ra","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erandi","family":"Escamilla-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Sol\u00eds-Soto","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Facultad de Odontolog\u00eda, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Mar\u00eda","family":"Garc\u00eda-Cuellar","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesennia","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Investigaci\u00f3n B\u00e1sica, Instituto Nacional de Cancerolog\u00eda, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha Maribel","family":"Flores-Trevi\u00f1o","sequence":"additional","affiliation":[{"name":"Servicios de Infectologia, Hospital Universitario, Facultad de Medicina, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, UANL, Monterrey, Nuevo Le\u00f3n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3894-597X","authenticated-orcid":false,"given":"Nayely","family":"Pineda-Aguilar","sequence":"additional","affiliation":[{"name":"Advanced Materials Research Center, CIMAV Unidad Monterrey, Nuevo Leon, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Valerio","family":"Cauich-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n, Unidad de Materiales, M\u00e9rida, Yucat\u00e1n, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Meester","sequence":"additional","affiliation":[{"name":"Universidad de Monterrey, Departamento de Ciencias B\u00e1sicas, San Pedro Garza Garc\u00eda, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shankararaman","family":"Chellam","sequence":"additional","affiliation":[{"name":"Texas A&M University, College Station, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"bibr1-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.12.001"},{"key":"bibr2-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"bibr3-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1066990"},{"key":"bibr4-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027"},{"key":"bibr5-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133382"},{"key":"bibr6-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.12.013"},{"key":"bibr7-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"bibr8-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020389"},{"key":"bibr9-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3390\/bios13010106"},{"key":"bibr10-22808000241236590","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2022-0142"},{"key":"bibr11-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1021\/nn3043463"},{"key":"bibr12-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1007\/s12645-013-0046-3"},{"key":"bibr13-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212831"},{"key":"bibr14-22808000241236590","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.2018-173"},{"key":"bibr15-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000863"},{"key":"bibr16-22808000241236590","first-page":"1","volume":"20","author":"Garc\u00eda-Cuellar CM","year":"2022","journal-title":"J Appl Biomater Funct Mater"},{"key":"bibr17-22808000241236590","first-page":"1","volume":"21","author":"Garc\u00eda-Cuellar CM","year":"2023","journal-title":"J Appl Biomater Funct Mater"},{"key":"bibr18-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2023.04.004"},{"key":"bibr19-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2475067"},{"key":"bibr20-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2006.7.s2-49"},{"key":"bibr21-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-014-2456-5"},{"key":"bibr22-22808000241236590","first-page":"1","volume":"20","author":"Torres-Betancourt JA","year":"2022","journal-title":"J Appl Biomater Funct Mater"},{"key":"bibr23-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2012.1423"},{"key":"bibr24-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1177\/2472630318811108"},{"key":"bibr25-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i43.4846"},{"key":"bibr26-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-020-02028-0"},{"key":"bibr27-22808000241236590","first-page":"41","volume":"91","author":"Kolasi\u0144ski W.","year":"2018","journal-title":"Pol Przegl Chir"},{"key":"bibr28-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.062"},{"key":"bibr29-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2014.08.008"},{"key":"bibr30-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01134-6"},{"key":"bibr31-22808000241236590","doi-asserted-by":"publisher","DOI":"10.7150\/thno.64805"},{"key":"bibr32-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.120139"},{"key":"bibr33-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2018.1555765"},{"key":"bibr34-22808000241236590","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S206084"},{"key":"bibr35-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2952085"},{"key":"bibr36-22808000241236590","doi-asserted-by":"publisher","DOI":"10.3762\/bjnano.7.178"},{"key":"bibr37-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.08.037"},{"key":"bibr38-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202100413"},{"key":"bibr39-22808000241236590","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c00865"},{"key":"bibr40-22808000241236590","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S179095"}],"container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22808000241236590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22808000241236590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22808000241236590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:19Z","timestamp":1777492639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22808000241236590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":40,"alternative-id":["10.1177\/22808000241236590"],"URL":"https:\/\/doi.org\/10.1177\/22808000241236590","relation":{},"ISSN":["2280-8000","2280-8000"],"issn-type":[{"value":"2280-8000","type":"print"},{"value":"2280-8000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"22808000241236590"}}