{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:26:43Z","timestamp":1777789603683,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>\n                    Numerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously. Herein, monodisperse poly(\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    -isopropylacrylamide) (PNIPAAm) hollow nanocapsules were synthesized at the interface of a water-in-oil (W\/O) single emulsion via Shirasu porous glass (SPG) membrane emulsification and UV-initiated polymerization. In water solutions, the PNIPAAm nanocapsules were able to encapsulate VA and form a new nanoscale water-soluble drug delivery system, namely, PNIPAAm-VA. In vitro experiments showed that PNIPAAm and PNIPAAm-VA had no cytotoxicity toward human bone marrow mesenchymal stem cells. In addition, the slow hydrolysis of PNIPAAm-VA in vitro led to the progressive release of VA, which was discharged at more than 50% and 80% of its initial concentration within 10\u2009days at 37\u00b0C and 40\u00b0C, respectively; this subsequently inhibited the growth of methicillin-resistant Staphylococcus aureus bacteria. We believe that our PNIPAAm-VA nanoparticles can potentially be used as an effective injectable for temperature-sensitive materials in vivo to achieve the localized controlled release of drugs as safe and specific therapeutic agents.\n                  <\/jats:p>","DOI":"10.1177\/22808000241291824","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T06:38:01Z","timestamp":1742020681000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Controlled release and antibioticeffect of vancomycin-loaded poly(\n                    <i>N<\/i>\n                    -isopropylacrylamide) nanoparticles as a smart drug delivery system"],"prefix":"10.1177","volume":"23","author":[{"given":"Liang","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanlong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, People\u2019s Hospital of Qingdao West Coast New Area, Qingdao, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-1822","authenticated-orcid":false,"given":"Jian","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Shenzhen University General Hospital, Shenzhen, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.01350"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1538574419886957"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/284294"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.180093"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17448"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.07.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.04.026"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2018.03.003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.11.016"},{"issue":"8","key":"e_1_3_3_11_2","first-page":"1935","article-title":"Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass\/PLGA composite scaffolds for bone regeneration in infected bone defects","volume":"46","author":"Cheng T","year":"2017","unstructured":"Cheng T, Qu H, Zhang G, et al Osteogenic and antibacterial properties of vancomycin-laden mesoporous bioglass\/PLGA composite scaffolds for bone regeneration in infected bone defects. 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