{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:31:28Z","timestamp":1788957088531,"version":"build-2803163510"},"reference-count":83,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>In this study, biocomposite membranes were developed by incorporating resveratrol (RSV)-loaded PCL-PEG composites, modified with graphene oxide (GO) and hydroxyapatite (HAP). The aim was to enhance hydrophilicity with GO and improve bioactivity with HAP. The release kinetics of RSV was evaluated by using Franz diffusion cells and compared with various kinetic models, including Korsmeyer-Peppas, Higuchi, and Baker, all of which showed high correlation coefficients ( R\u00b2) close to 0.99. Mechanical tests was performed to determine the suitability of these membranes for tissue engineering applications. The composite membrane modified with GO and HAP exhibited tensile strength of 105.2\u2009\u00b1\u20095.8\u2009MPa, tensile modulus of 3895\u2009\u00b1\u2009159\u2009MPa, elongation at break of 8.4\u2009\u00b1\u20090.9%, and toughness of 5.88\u2009\u00b1\u20090.46\u2009MJ\/m\u00b3. In vitro cell adhesion studies, visualized using DAPI fluorescence staining, demonstrated increased cell adhesion to the composite membranes over periods of 1, 3, 5, 7, and 14\u2009days. These findings highlight the potential of the RSV-loaded PCL-PEG membranes, enhanced with GO and HAP, for applications in bone tissue engineering.<\/jats:p>","DOI":"10.1177\/22808000251314087","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:20:57Z","timestamp":1738542057000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Resveratrol-loaded PCL-PEG\/GO\/HAP biocomposite bone membranes: Evaluation of mechanical properties, release kinetics, and cellular response"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6229-2157","authenticated-orcid":false,"given":"Bet\u00fcl Meryem","family":"Arpacay","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Fatih Sultan Mehmet Vak\u0131f University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-2404","authenticated-orcid":false,"given":"Fatih","family":"Ciftci","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Fatih Sultan Mehmet Vak\u0131f University, Istanbul, Turkey"},{"name":"Department of Technology Transfer Office, Fatih Sultan Mehmet Vak\u0131f University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-0598","authenticated-orcid":false,"given":"Ali Can","family":"\u00d6zarslan","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Department of Metallurgical and Materials Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey"},{"name":"Health Biotechnology Joint Research and Application Center of Excellence, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-8952","authenticated-orcid":false,"given":"Mustafa","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA"},{"name":"Center for Advanced Orthopedics Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-4953","authenticated-orcid":false,"given":"Mine","family":"Kucak","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Yildiz Technical University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6076-1715","authenticated-orcid":false,"given":"Aslihan","family":"Yelkenci","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Pediatric Dentistry, University of Health Sciences, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,2]]},"reference":[{"key":"bibr1-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02772-0"},{"key":"bibr2-22808000251314087","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01260"},{"key":"bibr3-22808000251314087","doi-asserted-by":"publisher","DOI":"10.3928\/0147-7447-20020502-04"},{"key":"bibr4-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.04.273"},{"key":"bibr5-22808000251314087","doi-asserted-by":"publisher","DOI":"10.18596\/jotcsa.1313562"},{"key":"bibr6-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoso.2024.101152"},{"key":"bibr7-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2019.03.047"},{"key":"bibr8-22808000251314087","doi-asserted-by":"publisher","DOI":"10.3390\/polym16010129"},{"key":"bibr9-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/app.39835"},{"key":"bibr10-22808000251314087","doi-asserted-by":"publisher","DOI":"10.3390\/ma11081430"},{"key":"bibr11-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2022.106206"},{"key":"bibr12-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA14061G"},{"key":"bibr13-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b00862"},{"key":"bibr14-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1177\/0885328218763665"},{"key":"bibr15-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03086-0"},{"key":"bibr16-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120381"},{"key":"bibr17-22808000251314087","doi-asserted-by":"publisher","DOI":"10.7317\/pk.2014.38.2.156"},{"key":"bibr18-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b00699"},{"key":"bibr19-22808000251314087","first-page":"121131","volume":"7","author":"Dong L","year":"2017","journal-title":"Scient Rep"},{"key":"bibr20-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2017.06.052"},{"key":"bibr21-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.05.021"},{"key":"bibr22-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-01684-9"},{"key":"bibr23-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53260-4"},{"key":"bibr24-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-023-01416-z"},{"key":"bibr25-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-018-0059-4"},{"key":"bibr26-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123769"},{"key":"bibr27-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-022-02499-2"},{"key":"bibr28-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-018-1526-0"},{"key":"bibr29-22808000251314087","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2021.15.1.12"},{"key":"bibr30-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.137330"},{"key":"bibr31-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s10971-023-06264-x"},{"key":"bibr32-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/app.55874"},{"key":"bibr33-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceramint.2023.01.075"},{"key":"bibr34-22808000251314087","first-page":"474","volume-title":"Proceedings of the fiber society 2009 spring conference","author":"Khenoussi N","year":"2009"},{"key":"bibr35-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s00289-019-02824-w"},{"key":"bibr36-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63239-5.00003-2"},{"key":"bibr37-22808000251314087","doi-asserted-by":"publisher","DOI":"10.37358\/MP.21.3.5523"},{"key":"bibr38-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00010E"},{"key":"bibr39-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-021-01976-1"},{"key":"bibr40-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2020.989"},{"key":"bibr41-22808000251314087","first-page":"1046","volume-title":"CEFood 2012 - Proceedings of 6th Central European congress on food","author":"Isailovi\u0107 BD","year":"2012"},{"key":"bibr42-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2021.2008391"},{"key":"bibr43-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2022.111000"},{"key":"bibr44-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2019.122050"},{"key":"bibr45-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37262"},{"key":"bibr46-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.10.018"},{"key":"bibr47-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2020.1805761"},{"key":"bibr48-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.2c04939"},{"key":"bibr49-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1080\/1023666X.2022.2068242"},{"key":"bibr50-22808000251314087","doi-asserted-by":"publisher","DOI":"10.36306\/konjes.1328688"},{"key":"bibr51-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33648"},{"key":"bibr52-22808000251314087","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00218"},{"key":"bibr53-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36097"},{"key":"bibr54-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2022.2025637"},{"key":"bibr55-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s00391-019-01595-3"},{"key":"bibr56-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123110"},{"key":"bibr57-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtchem.2018.03.005"},{"key":"bibr58-22808000251314087","first-page":"751","volume":"17","author":"Zhang Z","year":"2022","journal-title":"Asian J Pharmac Sci"},{"key":"bibr59-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1021\/mp400342f"},{"key":"bibr60-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2022.2112678"},{"key":"bibr61-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050215"},{"key":"bibr62-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2013.1585"},{"key":"bibr63-22808000251314087","doi-asserted-by":"publisher","DOI":"10.11113\/mjfas.v17n3.2183"},{"key":"bibr64-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.2c01162"},{"key":"bibr65-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2018.09.012"},{"key":"bibr66-22808000251314087","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S226517"},{"key":"bibr67-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3202"},{"key":"bibr68-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.03.009"},{"key":"bibr69-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2020.04.094"},{"key":"bibr70-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-019-01613-w"},{"key":"bibr71-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1177\/0883911515569918"},{"key":"bibr72-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07409"},{"key":"bibr73-22808000251314087","first-page":"49","volume":"13","author":"Nareswari TL","year":"2023","journal-title":"J Appl Pharmac Sci"},{"key":"bibr74-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1039\/C3BM60192G"},{"key":"bibr75-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.009"},{"key":"bibr76-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2018.01.001"},{"key":"bibr77-22808000251314087","doi-asserted-by":"publisher","DOI":"10.3390\/ma13112631"},{"key":"bibr78-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.02.015"},{"key":"bibr79-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202300843"},{"key":"bibr80-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2010.09.008"},{"key":"bibr81-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1159\/000527825"},{"key":"bibr82-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2222"},{"key":"bibr83-22808000251314087","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.07.029"}],"container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22808000251314087","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22808000251314087","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22808000251314087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:27Z","timestamp":1777492647000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22808000251314087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":83,"alternative-id":["10.1177\/22808000251314087"],"URL":"https:\/\/doi.org\/10.1177\/22808000251314087","relation":{},"ISSN":["2280-8000","2280-8000"],"issn-type":[{"value":"2280-8000","type":"print"},{"value":"2280-8000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"22808000251314087"}}