{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:46:39Z","timestamp":1793515599943,"version":"4.5.0"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Bioactive cerium-doped (Ce-BGs) glasses with proven antioxidant properties, which may reduce post-implant oxidative stress, were studied in vitro and in vivo to evaluate their application in bone regeneration. Based on the Kokubo (K) composition, they contain 3.6 and 5.3\u2009mol% cerium (referred to as K3.6 and K5.3, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Ce-BGs were synthesized by melting and sieved to produce granules (size range\u2009=\u2009200\u2013500\u2009\u00b5m). In vitro studies were conducted against MLO-Y4 cells using direct Neutral Red (NR) and indirect Bromo-2-deoxyUridine (BrdU) assays to assess cell viability and proliferation respectively. In vivo studies were carried out using a New Zealand white rabbit model to evaluate bone healing potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion:<\/jats:title>\n                    <jats:p>NR results showed a significant increase in cell viability for Ce-BGs: 77% for K and 79 and 85% for K3.6 and K5.3, after 24\u2009h. After 72\u2009h, cell viability decreased for K to 58% and increased for K3.6 and K5.3 (76% and 116% respectively). Cerium inhibits cell proliferation in BrdU assay as explainable by the increased durability of Ce-BGs. In vivo studies, after 30 and 60\u2009days, revealed a delayed degradation for Ce-BGs that can stimulate the osteo-regeneration without inflammatory or degenerative effects. Moreover, the new bone area (NBA) was higher for Ce-BGs compared to control; after 60\u2009days 32% for K5.3 versus 21% for K.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Ce-BGs granules show improved direct cytocompatibility in vitro and enhance the long-term bone remodeling process in vivo, contributing to a more controlled and effective bone healing compared to the K granules. This improved behavior can be linked to the antioxidant and anti-inflammatory properties of cerium, that can assist bone regeneration and reduce implant-associated inflammation, and to their slower dissolution rate that supports the controlled release of ions. These results suggest Ce-BGs as a promising device for therapeutic applications on\n                      <jats:italic toggle=\"yes\">hard<\/jats:italic>\n                      tissues.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22808000251326794","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:19:02Z","timestamp":1745457542000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Enhanced bone regeneration with cerium-doped bioactive glasses: In vitro and in vivo study"],"prefix":"10.1177","volume":"23","author":[{"given":"Roberta","family":"Salvatori","sequence":"first","affiliation":[{"name":"Biomaterials Laboratory, Department of Medical and Surgical Sciences for Mothers, Children, and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5281-6840","authenticated-orcid":false,"given":"Alexandre","family":"Anesi","sequence":"additional","affiliation":[{"name":"Biomaterials Laboratory, Department of Medical and Surgical Sciences for Mothers, Children, and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Chiarini","sequence":"additional","affiliation":[{"name":"Biomaterials Laboratory, Department of Medical and Surgical Sciences for Mothers, Children, and Adults, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Di Bartolomeo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arrigo","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery and Odontostomatology, Department of Surgical, Odontostomatological and Maternal-Infant Sciences, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4845-5930","authenticated-orcid":false,"given":"Chiara","family":"Cavazzoli","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Zambon","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0772-6037","authenticated-orcid":false,"given":"Gigliola","family":"Lusvardi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.08.023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.05.062"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.798393"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.07.019"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-006-0432-z"},{"key":"e_1_3_2_7_2","first-page":"27","article-title":"Bioactive glasses in soft tissue repair","volume":"94","author":"Miguez-Pacheco V","year":"2015","unstructured":"Miguez-Pacheco V, Greenspan D, Hench LL, et al Bioactive glasses in soft tissue repair. 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