{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:27:32Z","timestamp":1777789652703,"version":"3.51.4"},"reference-count":110,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Second Affiliated Hospital of Nanchang University Funding Program","award":["2023efyA02"],"award-info":[{"award-number":["2023efyA02"]}]},{"name":"Science and Technology Research Project of Jiangxi Provincial Department of Education-Youth Project","award":["GJJ2400114"],"award-info":[{"award-number":["GJJ2400114"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460103"],"award-info":[{"award-number":["82460103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460104"],"award-info":[{"award-number":["82460104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Science and Technology Innovation Project of Jiangxi Provincial Health Commission","award":["2024ZD005"],"award-info":[{"award-number":["2024ZD005"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Abdominal aortic aneurysm (AAA), defined as a permanent and often asymptomatic dilatation of the abdominal aorta, poses a significant threat of rupture with high mortality, yet lacks effective pharmacological interventions for stabilisation or regression. Current surgical options are invasive or require strict anatomical suitability, leaving patients with small aneurysms under passive surveillance. This critical gap underscores the urgent need for novel therapeutic strategies. Nanomedicine has emerged as a promising approach, offering solutions for targeted drug delivery, precise imaging, and dynamic monitoring of AAA progression. This review comprehensively analyses recent advances in nanomaterial-based systems for AAA management. We classify and discuss key nanocarriers\u2014inorganic nanomaterials, organic nanomaterials, and hybrid nanomaterials\u2014highlighting their unique design strategies, targeting mechanisms, and therapeutic functions. Specific applications include the targeted delivery of anti-inflammatory agents, modulation of matrix metalloproteinase activity via siRNA delivery, protection of vascular smooth muscle cells (VSMCs) from oxidative stress and apoptosis, and strategies for in situ vascular repair and regeneration. Furthermore, the role of nanomaterials in enhanced diagnostics and intelligent sensing for rupture risk prediction is explored. Despite encouraging preclinical results, challenges regarding long-term biosafety, translatability from rodent models to human pathophysiology, and optimisation of hemodynamic delivery remain significant hurdles. Future directions involve closed-loop theranostic systems, artificial intelligence integration, hemodynamic-optimised nanoparticle design, and exploring gene-editing nanocarriers. This review concludes that engineered nanomaterials hold substantial potential to transform AAA management from passive monitoring to active prevention and precision therapy, paving the way for future clinical translation.<\/jats:p>","DOI":"10.1177\/22808000251379140","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:34:33Z","timestamp":1758807273000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Nanomaterials in abdominal aortic aneurysm: From targeted therapy to smart vascular repair"],"prefix":"10.1177","volume":"23","author":[{"given":"Xiya","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, China"},{"name":"Queen Mary College of Nanchang University, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihan","family":"You","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, China"},{"name":"Queen Mary College of Nanchang University, Jiangxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-6692","authenticated-orcid":false,"given":"Weimin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenpeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiacong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, The Second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.09.011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.17021"},{"key":"e_1_3_2_4_2","first-page":"165","article-title":"Abdominal aortic aneurysm","volume":"106","author":"Haque K","year":"2022","unstructured":"Haque K, Bhargava P. Abdominal aortic aneurysm. Am Fam Physician 2022; 106: 165\u2013172.","journal-title":"Am Fam Physician"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/18.218"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.09.020"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.18638"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.180"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ro.2014.10.003"},{"key":"e_1_3_2_10_2","first-page":"166","article-title":"Pathophisiology of abdominal aortic aneurysm: biomarkers and novel therapeutic targets","volume":"31","author":"Torres-Fonseca M","year":"2019","unstructured":"Torres-Fonseca M, Galan M, Martinez-Lopez D, et al. Pathophisiology of abdominal aortic aneurysm: biomarkers and novel therapeutic targets. Clin Investig Arterioscler 2019; 31: 166\u2013177.","journal-title":"Clin Investig Arterioscler"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.09.56"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.085498"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad386"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66459-8"},{"key":"e_1_3_2_15_2","first-page":"1198","article-title":"Abdominal aortic aneurysm","volume":"73","author":"Upchurch GR","year":"2006","unstructured":"Upchurch GRJr, Schaub TA. Abdominal aortic aneurysm. Am Fam Physician 2006; 73: 1198\u20131204.","journal-title":"Am Fam Physician"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1324406"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000245819.32762.cb"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.52"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1252"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150547"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000216"},{"key":"e_1_3_2_22_2","first-page":"7213760","article-title":"Modulation of immune-inflammatory responses in abdominal aortic aneurysm: emerging molecular targets","volume":"1","author":"Li H","year":"2018","unstructured":"Li H, Bai S, Ao Q, et al. Modulation of immune-inflammatory responses in abdominal aortic aneurysm: emerging molecular targets. J Immunol Res 2018; 1: 7213760.","journal-title":"J Immunol Res"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450119666171227223331"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/1570161115666170413145705"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp155"},{"key":"e_1_3_2_26_2","first-page":"1","volume":"2","author":"Medical Advisory Secretariat. Endovascular repair of abdominal aortic aneurysm: an evidence-based analysis","year":"2002","unstructured":"Medical Advisory Secretariat. Endovascular repair of abdominal aortic aneurysm: an evidence-based analysis. Ont Health Technol Assess Ser 2002; 2: 1\u201346.","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.735274"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108652"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0114-9"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016108785909689"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.12.02241"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0634-5"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.112319"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.003023"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2019-0352"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2024.2377747"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12958"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/145749690809700208"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220795"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.03.006"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.1"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.2310\/6670.2007.00055"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000106016.13624.4a"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010385"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2023.102881"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.09.013"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6673-2-16"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707130"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00151"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1872"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902409"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.05.028"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00383"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.665846"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1879315"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S224024"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12255"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026620666200825170030"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00226-0"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1402"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.11.190"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2014.02.002"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.010495"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.3463"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01342.x"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-016-1958-5"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.12.140"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34441"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202402141"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37618"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228702"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11058"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c00387"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202405761"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-016-1401-8"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174487"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10924-025-03496-6"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2188"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02756-2"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06258"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37667"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1101\/2024.06.17.599454"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.075"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.4028\/b-wjQRP6"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.3791\/66674"},{"key":"e_1_3_2_87_2","article-title":"Animal models, pathogenesis, and potential treatment of thoracic aortic aneurysm","volume":"25","author":"Wang Y","year":"2024","unstructured":"Wang Y, Panicker IS, Anesi J, et al. Animal models, pathogenesis, and potential treatment of thoracic aortic aneurysm. Int J Mol Sci 2024; 25: e020901.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000363"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199609270-00017"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.126120"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-02156-3"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101557"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101337"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c02821"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2024.148820"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51030-4"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.746796"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.05.025"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0344-3"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44902-2"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2021.3116764"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02892-9"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.125478"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1801"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13111793"},{"key":"e_1_3_2_106_2","article-title":"Gene and photothermal combination therapy: principle, materials, and amplified anticancer intervention","volume":"20","author":"Tang F","year":"2024","unstructured":"Tang F, Ding A, Xu Y, et al. Gene and photothermal combination therapy: principle, materials, and amplified anticancer intervention. Small 2024; 20: e2307078.","journal-title":"Small"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08993"},{"key":"e_1_3_2_108_2","article-title":"The expansion of artificial intelligence in modifying and enhancing the current management of abdominal aortic aneurysms: a literature review","volume":"16","author":"Khalid U","year":"2024","unstructured":"Khalid U, Stoev HA, Yavorov B, et al. The expansion of artificial intelligence in modifying and enhancing the current management of abdominal aortic aneurysms: a literature review. Cureus 2024; 16: e66398.","journal-title":"Cureus"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-02085-z"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01905-1"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16526"}],"container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22808000251379140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22808000251379140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22808000251379140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:35Z","timestamp":1777492655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22808000251379140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":110,"alternative-id":["10.1177\/22808000251379140"],"URL":"https:\/\/doi.org\/10.1177\/22808000251379140","relation":{},"ISSN":["2280-8000","2280-8000"],"issn-type":[{"value":"2280-8000","type":"print"},{"value":"2280-8000","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"article-number":"22808000251379140"}}