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This study developed a thermosensitive chitosan\/\u03b2-glycerophosphate (CS-\u03b2-GP) hydrogel reinforced with graphene oxide (GO) for the localized co-delivery of paclitaxel (PTX) and dexamethasone (DEX). The incorporation of GO increased the storage modulus from approximately 3.95\u2009kPa to 6.96\u2009kPa, enhancing mechanical strength and accelerating gelation near body temperature (~36\u00b0C\u201337\u00b0C). SEM analysis revealed a porous, interconnected structure that supports drug delivery, while swelling was moderate (~145% at 6\u2009h) and degradation resistance was improved, with the hydrogel retaining 80% of its mass in PBS after 30\u2009days. Drug loading favored PTX (70% at 60\u2009\u03bcg\/mL) over DEX (17%) with sustained release profiles. Biologically, the dual-drug hydrogel (CS-\u03b2-GP-GO@PTX-DEX) selectively reduced hVSMC viability, migration, proliferation (~30%, ~20%, and ~30%, respectively), while preserving endothelial cell viability (~60%) and lowering proinflammatory cytokines (IL-1\u03b2 ~100\u2009pg\/mL, IL-6 ~110\u2009pg\/mL, TNF-\u03b1 ~70\u2009pg\/mL). These findings establish the CS-\u03b2-GP-GO@PTX-DEX hydrogel as a mechanically robust, selective, and effective platform for preventing restenosis and enhancing vascular tissue regeneration.<\/jats:p>","DOI":"10.1177\/22808000261421276","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T16:10:59Z","timestamp":1771085459000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Graphene oxide\u2013reinforced thermosensitive hydrogel co-delivering paclitaxel and dexamethasone for restenosis prevention"],"prefix":"10.1177","volume":"24","author":[{"given":"Jinping","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Radiological Diagnosis, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiological Diagnosis, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiological Diagnosis, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiological Diagnosis, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5931-0562","authenticated-orcid":false,"given":"Feizhou","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiological Diagnosis, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.001"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1288"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0366"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2016.07.106"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.11.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030517"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.936922"},{"issue":"3","key":"e_1_3_2_10_2","first-page":"321","article-title":"Antiproliferative drugs for restenosis prevention","volume":"5","author":"Habib A","year":"2016","unstructured":"Habib A, Finn AV. 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