{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:27:51Z","timestamp":1777789671937,"version":"3.51.4"},"reference-count":85,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Silver nanoparticles (AgNPs) are increasingly explored as alternatives to conventional antibiotics in wound care due to their broad-spectrum antimicrobial activity. This study evaluates the antibacterial performance of \u03b1-lipoic acid-functionalized silver nanoparticles (AgNPs-LA) using an integrated experimental-computational approach combining molecular dynamics simulations and experimental validation. AgNPs-LA were synthesized via a controlled hydrothermal method employing biogenic reduction of silver ions to minimize cytotoxicity. Structural and compositional analyses confirmed successful surface functionalization with \u03b1-lipoic acid and D-glucose. Morphological characterization revealed predominantly spherical nanoparticles with diameters ranging from 37 to 90\u2009nm. Antimicrobial agar disk diffusion assays demonstrated concentration-dependent inhibition of\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    . Specifically, AgNPs-LA at 40\u2009\u03bcg\/mL produced inhibition zones statistically comparable to gentamicin against\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    \u2009\n                    <jats:italic toggle=\"yes\">aureus<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">P.<\/jats:italic>\n                    \u2009\n                    <jats:italic toggle=\"yes\">aeruginosa<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Molecular dynamics simulations performed under isothermal-isochoric (constant number of particles, volume, and temperature; NVT) canonical ensemble indicated that the disulfide moiety of lipoic acid serves as the primary anchoring group to the silver surface, conferring stability through the formation of a structured hydrophobic surface layer. This interfacial configuration enhances nanoparticle stability and may improve pharmacokinetic clearance, thereby reducing the risk of systemic toxicity. Collectively, these findings highlight the potential of AgNPs-LA as a safe and effective antimicrobial platform for wound management applications.\n                  <\/jats:p>","DOI":"10.1177\/22808000261442268","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:47:36Z","timestamp":1776829656000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the antibacterial properties of lipoic acid-functionalized silver nanoparticles"],"prefix":"10.1177","volume":"24","author":[{"given":"Lhana Erylle A.","family":"dela Cruz","sequence":"first","affiliation":[{"name":"Department of Mining, Metallurgical and Materials Engineering, University of the Philippines, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-9625","authenticated-orcid":false,"given":"Richard D.","family":"Espiritu","sequence":"additional","affiliation":[{"name":"Department of Mining, Metallurgical and Materials Engineering, University of the Philippines, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-9187","authenticated-orcid":false,"suffix":"Jr.","given":"Eduardo R.","family":"Magdaluyo","sequence":"additional","affiliation":[{"name":"Department of Mining, Metallurgical and Materials Engineering, University of the Philippines, Quezon City, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma12132176"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.11.004"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122085"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.07.016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.10.125"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122139"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.04.194"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-822238-6.00027-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.10.043"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2018.10.010"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092392"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ528"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150414123800"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.244-269.2001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1023291"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.889175"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA44507K"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtcomm.2022.103914"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.02.043"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.130097"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.12.106"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2012.11.077"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.09.030"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2022.129708"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.04.026"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.06.131"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2015.11.002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1515\/ejnm-2014-0032"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.00977.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137178"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.733743"},{"key":"e_1_3_3_33_2","article-title":"Silver nanoparticle antibacterial efficacy and resistance development in key bacterial species","volume":"5","author":"Ellis DH","year":"2019","unstructured":"Ellis DH, Maurer-Gardner EI, Sulentic CEW, et al. 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