{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:57:02Z","timestamp":1781524622217,"version":"3.54.1"},"reference-count":63,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    This study evaluated the effect of calcium-rich nanohydroxyapatite (nano-HA) as an intracanal medicament on root fracture resistance compared with calcium hydroxide (CH). Forty-eight caries-free maxillary central incisors were instrumented and randomly assigned to a two-factor design (two medicaments\u2009\u00d7\u2009two sealers), yielding four experimental groups (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200912\/group): CH\u2009+\u2009resin-based sealer, CH\u2009+\u2009bioceramic-based sealer, nano-HA\u2009+\u2009resin-based sealer, and nano-HA\u2009+\u2009bioceramic-based sealer. The medicaments were applied and stored in simulated body fluid at 37\u2009\u00b0C and 100% humidity for 10\u2009days. After removal, the canals were obturated with heated gutta-percha using either a resin-based or a bioceramic-based sealer, and were then stored for an additional 28\u2009days. Vertical fracture resistance was measured using an Instron Universal Testing Machine. Data were analyzed using two-way ANOVA (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The nano-HA groups showed a higher mean fracture resistance (924.04\u2009N) than the CH groups (818.54\u2009N). The highest fracture resistance was observed in the nano-HA\u2009+\u2009bioceramic-based sealer group (1020.38\u2009N), whereas the lowest was observed in the CH\u2009+\u2009resin-based sealer group (665.83\u2009N). The main effect of sealer type was statistically significant (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while no significant interaction between medicament and sealer type was detected. Within the limitations of this in vitro study using static vertical loading, sealer type had a large, statistically significant effect on fracture resistance, with the bioceramic-based sealer yielding higher values than the resin-based sealer. Although the nano-HA groups exhibited numerically higher fracture resistance than calcium hydroxide, the main effect of intracanal medicament did not reach statistical significance. These findings are limited to laboratory conditions and should not be directly extrapolated to long-term clinical performance.\n                  <\/jats:p>","DOI":"10.1177\/22808000261446890","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T15:16:33Z","timestamp":1781363793000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fracture resistance of roots obturated with bioceramic or resin-based sealers after nanohydroxyapatite and calcium hydroxide dressing"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-1551","authenticated-orcid":false,"given":"Olcay","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Karab\u00fck University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Ka\u015f\u0131k\u00e7\u0131","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Kocaeli University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"\u015eirino\u011flu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Kocaeli Health and Technology University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7987","authenticated-orcid":false,"given":"Turkan","family":"Kopac","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Zonguldak B\u00fclent Ecevit University, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1992.tb00743.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13731"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081748"},{"key":"e_1_3_2_5_2","article-title":"Cytotoxicity and biocompatibility of root canal sealers: a review on recent studies","volume":"20","author":"\u00d6zdemir O","year":"2022","unstructured":"\u00d6zdemir O, Kopac T. 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