{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:05:47Z","timestamp":1779433547391,"version":"3.53.1"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100002280","name":"Plastic Surgery Foundation","doi-asserted-by":"publisher","award":["Innovation in Wound Care Research"],"award-info":[{"award-number":["Innovation in Wound Care Research"]}],"id":[{"id":"10.13039\/100002280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    Biofilm-colonized chronic wounds are difficult to treat due to a constantly evolving microbiome. In this study, a cHG augmented with antibiotics was examined for the topical treatment of biofilm-challenged wounds in vivo. Two studies were performed in series using a murine stented wound model. Mice were divided into four groups: control (wound only), infection only (IO), infection\u2009+\u2009cHG (IcHG), and infection\u2009+\u2009cHG\u2009+\u2009antibiotics (IcHG\u2009+\u2009Abx). We first examined\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    biofilms treated with gentamicin, and then MRSA biofilms treated with clindamycin. Wound healing was assessed using photography, immunohistochemistry, and histology. Systemic symptoms were monitored with hematological laboratory tests.\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    infected wounds treated with cHG\u2009+\u2009Abx healed faster and were protected from bacteremia. In the MRSA infected mice, wound treatment significantly affected the outcome, explaining 5.56% of total variance (ANOVA:\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    (3, 366)\u2009=\u200917.38,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Additionally, infected wounds treated with cHG\u2009+\u2009Abx demonstrated less inflammatory tissue and accelerated closure rate on day 8 (76.53%\u2009\u00b1\u20097.43% vs 48.40%\u2009\u00b1\u20094.95%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and day 14 (96.00%\u2009\u00b1\u20093.07% vs 82.38%\u2009\u00b1\u20098.24%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003), as compared to the infection only wounds. cHG offers a biocompatible, topical option with dual functionality: antibiotic augmentation to target biofilm pathogens, and a collagen-rich dressing to accelerate wound healing.\n                  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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel","family":"Sanchez Rangle","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Veterans Affairs Palo Alto Health Care System, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Veterans Affairs Palo Alto Health Care System, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, CA, USA"},{"name":"Division of Plastic and Reconstructive 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