{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:17:40Z","timestamp":1783423060841,"version":"3.54.6"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Joint Project of Pinnacle Disciplinary Group, the Second Affiliated Hospital of Chongqing Medical University","award":["2024201"],"award-info":[{"award-number":["2024201"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Applied Biomaterials &amp; Functional Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sonodynamic therapy (SDT) has emerged as a promising strategy for cancer treatment; however, its therapeutic efficacy is significantly limited by the hypoxic tumor microenvironment, particularly in breast cancer. To address this limitation, we developed a biomimetic nanoplatform capable of generating oxygen within the tumor microenvironment to enhance SDT performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Poly (lactic-co-glycolic acid) (PLGA) nanoparticles were co-loaded with catalase and the sonosensitizer IR780 and subsequently coated with 4T1 cancer cell membranes (CIP@4T1m NPs). A series of\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      experiments were conducted to evaluate tumor-targeting capability, hypoxia alleviation, singlet oxygen (\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) generation, antitumor efficacy, induction of immunogenic cell death (ICD), and activation of antitumor immune responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The resulting CIP@4T1m NPs were successfully fabricated and exhibited preferential accumulation in 4T1 tumor cells and orthotopic 4T1 tumor-bearing mice. Both\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      studies demonstrated that the nanoplatform partially relieved tumor hypoxia and significantly enhanced SDT-mediated\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      production and antitumor effects. Moreover, CIP@4T1m NPs combined with ultrasound induced ICD-associated changes, promoted dendritic cell maturation, facilitated the polarization of tumor-associated macrophages from the M2 to M1 phenotype, reduced regulatory T cell populations, and increased intratumoral CD8\n                      <jats:sup>+<\/jats:sup>\n                      T-cell infiltration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work describes a biomimetic nanoplatform that integrates homologous targeting with enzymatic oxygen generation to enhance SDT efficacy and promote antitumor immune responses in an orthotopic 4T1 breast cancer model. The proposed strategy offers a potential approach to mitigate hypoxia-associated limitations in cancer therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22808000261464863","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T09:16:42Z","timestamp":1783156602000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A biomimetic oxygen-generating nanoplatform for enhanced sonodynamic immune activation"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8491-1464","authenticated-orcid":false,"given":"Haiqin","family":"Liao","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University"},{"name":"The Second Xiangya Hospital, Central South University"},{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Clinical Research Center for Ultrasound and Treatment in Hunan Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Ding","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Hunan University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"},{"name":"The Second Xiangya Hospital, Central South University"},{"name":"Clinical Research Center for Ultrasound and Treatment in Hunan Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanliang","family":"Shang","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital, Central South University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.7162"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003214"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42509-7"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305392"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-023-01721-y"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00407G"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03485-w"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9056-0"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.002"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00843"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119755"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900730"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00699-x"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00893"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1039\/D5BM00189G"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122456"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-024-00920-9"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202104037"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b03568"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303835"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004853"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313670"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01332-8"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008026"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2023.09.006"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01885-w"},{"issue":"25","key":"e_1_3_6_30_2","first-page":"01368","article-title":"Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity","volume":"0092","author":"Gu JLY","year":"2025","unstructured":"Gu JLY, Chen Q, Song Z, et al. 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