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The Alginate\/calcium chloride (Alg\/CaCl\n                    <jats:sub>2<\/jats:sub>\n                    ) dressing was fabricated by crosslinking sodium alginate with calcium chloride, resulting in the formation of a stable gel network, which was subsequently freeze-dried to obtain a porous structure. In vitro evaluations were performed using L929 mouse fibroblasts to assess cytotoxicity, platelet aggregation, and platelet activation. The biosafety of the dressing was further examined using a rabbit skin irritation model following both topical application and subcutaneous injection. In addition, the pressure-assisted hemostatic effect of the dressing was evaluated using a customized compression device incorporating the Alg\/CaCl\n                    <jats:sub>2<\/jats:sub>\n                    dressing.\n                  <\/jats:p>\n                  <jats:p>\n                    The results demonstrated that the Alg\/CaCl\n                    <jats:sub>2<\/jats:sub>\n                    dressing promoted platelet aggregation and activation while exhibiting minimal cytotoxicity at most tested concentrations, indicating favorable biocompatibility. The dressing possessed a highly porous structure and excellent fluid absorption capacity. Furthermore, the sustained release of physiologically active calcium ions may facilitate platelet activation and fibrin formation, thereby accelerating the hemostatic process. In vivo assessments revealed no significant skin irritation or adverse tissue reactions following either topical application or subcutaneous injection, supporting its safety for biomedical applications. Moreover, compression testing in the animal model demonstrated that the Alg\/CaCl\n                    <jats:sub>2<\/jats:sub>\n                    dressing generated greater compressive force than commercially available hemostatic products, contributing to enhanced pressure-assisted hemostasis.\n                  <\/jats:p>","DOI":"10.1177\/22808000261469360","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:32:05Z","timestamp":1784035925000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a pressure hemostatic dressing with the coagulation properties of sodium alginate as a base material"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-0942","authenticated-orcid":false,"given":"Yu-Ju","family":"Lai","sequence":"first","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"},{"name":"National Defense Medical University"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yi","family":"Bai","sequence":"additional","affiliation":[{"name":"National Taiwan University of Science and Technology"},{"name":"National Taiwan University of Science and Technology"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Yu","family":"Hwang","sequence":"additional","affiliation":[{"name":"National Taiwan University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chi","family":"Wang","sequence":"additional","affiliation":[{"name":"Tri-Service General Hospital"},{"name":"National Defense Medical University"},{"name":"National Defense Medical University"},{"name":"National Defense Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339613"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200223"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2003.83.3.835"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0485"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2000.9.2.26338"},{"issue":"4","key":"e_1_3_4_8_2","first-page":"640","article-title":"Alginate dressings in wound care: a systematic review and meta-analysis of randomized clinical trials","volume":"14","author":"Qu Z","year":"2023","unstructured":"Qu Z, Wang Y, Niu Q, et al. 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