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In this study, robust antibacterial properties were successfully conferred onto electrospun silk fibroin nanofiber mats using a mussel-inspired polydopamine (PDA) dip-coating strategy. Primary dip-coating deposited a uniform PDA nanolayer that served as an adhesive scaffold, enabling subsequent anchoring of dopamine nanoparticles during secondary coating. This hierarchical structure markedly increased surface roughness and reactive catechol density. Antibacterial evaluation against\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    showed that secondary PDA-coated mats substantially reduced bacterial colonization relative to both primary-coated and unmodified controls. Secondary coating cycles further enhanced antibacterial performance. Cytocompatibility assessment performed according to ISO 10993-5 confirmed excellent biocompatibility of the modified mats, with no significant cytotoxicity observed. This simple, versatile, and antibiotic-free functionalization approach significantly improves the translational potential of silk fibroin nanofibers as next-generation antibacterial wound dressings.\n                  <\/jats:p>","DOI":"10.1177\/22808000261497115","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:18:30Z","timestamp":1791638310000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polydopamine-functionalized silk-based biomaterial for non-antibiotic antimicrobial therapy"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1979-779X","authenticated-orcid":false,"given":"Munguti Peter","family":"Muindi","sequence":"first","affiliation":[{"name":"University of Nairobi"},{"name":"Silk Origin limited, Department of Biomaterials and Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Mureithi","sequence":"additional","affiliation":[{"name":"University of Nairobi"},{"name":"KAVI Institute of Clinical Research, Department of Medical Microbiology & Immunology, College of Health Sciences, University of Nairobi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bosire","family":"Kefa","sequence":"additional","affiliation":[{"name":"University of Nairobi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anzala","family":"Omu","sequence":"additional","affiliation":[{"name":"KAVI Institute of Clinical Research, Department of Medical Microbiology & Immunology, College of Health Sciences, University of Nairobi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-6547","authenticated-orcid":false,"given":"George","family":"Ichoho","sequence":"additional","affiliation":[{"name":"KAVI Institute of Clinical Research, Department of Medical Microbiology & Immunology, College of Health Sciences, University of Nairobi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mbirua","family":"Elijah","sequence":"additional","affiliation":[{"name":"Silk Origin limited, Department of Biomaterials and Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gichuru","family":"Anthony","sequence":"additional","affiliation":[{"name":"Silk Origin limited, Department of Biomaterials and Engineering"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"e_1_3_7_2_2","first-page":"155","article-title":"Silk fibroin as a functional biomaterial for tissue engineering. 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