{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:45:47Z","timestamp":1782855947152,"version":"3.54.5"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54HD40093"],"award-info":[{"award-number":["U54HD40093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endometriosis and Pelvic Pain Disorders"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Problem:<\/jats:title>\n                    <jats:p>Perturbations in T-helper lymphocyte profiles have previously been associated with endometriosis related subfertility and conception failure. Hence a retrospective in vitro study was conducted to evaluate the relationship between T-regulatory (Treg) and T-helper 17 (Th17) lymphocytes in the eutopic endometrium of women with unexplained subfertility and correlate these profiles to their conception status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study:<\/jats:title>\n                    <jats:p>Eutopic endometrial biopsies were collected during the mid-secretory phase of the menstrual cycle, from women with unexplained subfertility. These samples were evaluated immunohistochemically for Treg and Th17 lymphocytes as well as the related proinflammatory cytokine, Interleukin-17 (IL-17). These eutopic endometrial T lymphocyte subpopulations were compared to the patients\u2019 conception status in subsequent cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Though Treg cells were not indicative of conception success in subsequent cycles, patients who maintained their subfertile (no conception) status were observed to have a higher Th17 cell count in their eutopic endometrium. The ratio of Treg:Th17 cell counts was significantly correlated to patient conception status as well. These trends stayed consistent irrespective of concurrent endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with a high proinflammatory Th17 lymphocyte profile and low Treg:Th17 ratio in their eutopic endometrium during the secretory phase of their menstrual cycle are more likely to not conceive in subsequent cycles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22840265211018544","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T16:11:35Z","timestamp":1622304695000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Altered eutopic endometrial T-regulatory and T-helper 17 lymphocyte ratio in women with unexplained subfertility"],"prefix":"10.1177","volume":"13","author":[{"given":"Malavika K","family":"Adur","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA"},{"name":"Department of Animal Science, Iowa State University, Ames, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea G","family":"Braundmeier-Fleming","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA"},{"name":"Department of Medical Microbiology, Immunology and Cell Biology, SIU School of Medicine, Springfield, IL, USA"},{"name":"Department of Obstetrics and Gynecology, SIU School of Medicine, Springfield, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A","family":"Lessey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Greenville Hospital System, Greenville, SC, USA"},{"name":"Department of Obstetrics and Gynecology, Wake Forest Baptist Health, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6578-5695","authenticated-orcid":false,"given":"Romana A","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"bibr1-22840265211018544","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09417-5"},{"key":"bibr2-22840265211018544","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7417.721"},{"key":"bibr3-22840265211018544","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6934(02)00146-3"},{"key":"bibr4-22840265211018544","doi-asserted-by":"publisher","DOI":"10.1002\/9781444393958.ch9"},{"key":"bibr5-22840265211018544","volume":"2020","author":"Fox CW","year":"2020","journal-title":"Hum Reprod 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