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Assuming local ischemia as an etiological factor, two cases in which topical nitroglycerin was used following surgical treatment of Dupuytren's disease are presented. In these patients, no raised scar formation developed during healing. At least six months after surgery, disease recurrence was not noted and the patients and surgeon reported improved skin quality. In the present study, the use of topical nitroglycerin, a local vasodilator, appeared to prevent recurrent scar formation, possibly through prevention of local ischemia. Further study and follow-up is necessary.<\/jats:p>","DOI":"10.1177\/229255031202000412","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T05:24:26Z","timestamp":1487827466000},"page":"249-250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative management of Dupuytren's disease with topical nitroglycerin"],"prefix":"10.1177","volume":"20","author":[{"given":"Patrick I","family":"Emelife","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell E","family":"Kling","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Wollstein","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"bibr1-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2002.32334"},{"key":"bibr2-229255031202000412","first-page":"2330","volume":"27","author":"Gosset J","year":"1951","journal-title":"Sem Hop"},{"key":"bibr3-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1308\/003588406X83104"},{"key":"bibr4-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1097\/01.bth.0000186794.90431.a4"},{"key":"bibr5-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2005.05.008"},{"key":"bibr6-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsb.2005.05.004"},{"key":"bibr7-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000101054.80392.88"},{"key":"bibr8-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(03)00013-5"},{"key":"bibr9-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"bibr10-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-009-0958-y"},{"key":"bibr11-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1007\/s00113-010-1808-6"},{"key":"bibr12-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)00449-2"},{"key":"bibr13-229255031202000412","first-page":"135","volume":"9","author":"Hueston JT","year":"1990","journal-title":"Ann Chir Main Memb Super"},{"key":"bibr14-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)00905-7"},{"key":"bibr15-229255031202000412","first-page":"156","volume":"74","author":"Murrell GA","year":"1992","journal-title":"Ann R Coll Surg Engl"},{"key":"bibr16-229255031202000412","first-page":"509","volume":"140","author":"Madden JW","year":"1975","journal-title":"Surg Gynecol Obstet"},{"key":"bibr17-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2009.061002"},{"key":"bibr18-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/j.ciresp.2009.12.013"},{"key":"bibr19-229255031202000412","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00032-8"},{"key":"bibr20-229255031202000412","first-page":"46","volume":"150","author":"Knobloch K","year":"2008","journal-title":"MMW Fortschritte der Medizin."}],"container-title":["Canadian Journal of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/229255031202000412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/229255031202000412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:59:53Z","timestamp":1777593593000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/229255031202000412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1177\/229255031202000412"],"URL":"https:\/\/doi.org\/10.1177\/229255031202000412","relation":{},"ISSN":["1195-2199"],"issn-type":[{"value":"1195-2199","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}