{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:33:25Z","timestamp":1791048805815,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T00:00:00Z","timestamp":1628553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"University of Manitoba, Department of Surgery","award":["317632-342100-2000"],"award-info":[{"award-number":["317632-342100-2000"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Plast Surg (Oakv)"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Merkel cell carcinoma (MCC) of the head and neck is a rare and aggressive non-melanoma skin cancer. The objective of this study was to assess the oncological outcome of MCC by retrospective review of electronic and paper records of a population-based cohort of 17 consecutive cases of the head and neck MCC without distant metastasis, diagnosed in Manitoba between 2004 and 2016. The average age of the patients at initial presentation was 74.1 \u00b1 14.4 years with 6 patients presenting with stage I, 4 with stage II, and 7 with stage III disease. Both surgery or radiotherapy alone were the primary treatment modalities in 4 patients each and the remaining 9 patients had a combination of surgery with adjuvant radiotherapy. During the median follow-up of 52 months, 8 patients had recurrent\/residual disease and 7 eventually died of it ( P = .001). Metastatic spread of disease to the regional lymph nodes was observed in 11 patients either at presentation or during the follow-up and to the distant sites in 3 patients. At the time of the last contact on November 30, 2020, 4 patients were alive and disease-free, 7 had died of disease, and 6 had died of other causes. The case fatality rate was 41.2%. Five-year disease-free and disease-specific survivals were 51.8% and 59.7%, respectively. The 5-year disease-specific survival was 75% for early stage MCC (stage I and II) and 35.7% for stage III MCC. Early diagnosis and intervention are crucial for disease control and improving survival.<\/jats:p>","DOI":"10.1177\/22925503211031934","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:42:27Z","timestamp":1628570547000},"page":"146-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Merkel Cell Carcinoma of the Head and Neck"],"prefix":"10.1177","volume":"31","author":[{"given":"Frances-Claire","family":"Eichorn","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arbind","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, CancerCare Manitoba, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-2738","authenticated-orcid":false,"given":"Kumar Alok","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"bibr1-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620040075020"},{"key":"bibr2-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq120"},{"key":"bibr3-22925503211031934","first-page":"2157","volume":"8","author":"Saini AT","year":"2015","journal-title":"Onco Targets Ther"},{"key":"bibr4-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5993-1"},{"key":"bibr5-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21787"},{"key":"bibr6-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.028"},{"key":"bibr7-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp139"},{"key":"bibr8-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2019.03.001"},{"key":"bibr9-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.004"},{"key":"bibr10-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1007\/s10434-001-0204-4"},{"key":"bibr11-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215116000153"},{"key":"bibr12-22925503211031934","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.131"},{"key":"bibr13-22925503211031934","unstructured":"National Comprehensive Cancer Network. 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