{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:17:01Z","timestamp":1787019421328,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Manitoba Firefighters Burn Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Plast Surg (Oakv)"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Necrotizing fasciitis (NF) is a life-threatening infectious disease that can result in significant morbidity and mortality. Previously identified factors have not been verified in a large population. The objective of this study is to further examine the relationship of patient factors in NF mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study is a retrospective review on patients \u226518 years old diagnosed with NF at the provincial referral centres from 2004 to 2016. The following data were examined: demographics, comorbidities, laboratory values, length of stay, and inhospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Three hundred forty patients satisfied the inclusion criteria: 297 survived and were discharged, 43 died in hospital. In multivariate analysis, a prognostic model for NF mortality identified age &gt;60 years, elevated creatinine, abnormal blood platelets, and group A \u03b2-hemolytic Streptococcus (GABS) infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Multiple factors were associated with mortality in NF. The strongest univariate association with mortality was age &gt;60 years. In addition, a history of hypertension and\/or dyslipidemia, renal disease, and the presence of GABS contributed to a predictive model for inhospital NF mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22925503211034830","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:19:44Z","timestamp":1634858384000},"page":"221-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictors of Mortality in Patients With Necrotizing Fasciitis: A Literature Review and Multivariate Analysis"],"prefix":"10.1177","volume":"31","author":[{"given":"Lindsey","family":"Kjaldgaard","sequence":"first","affiliation":[{"name":"College of Medicine, Med II Research Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Cristall","sequence":"additional","affiliation":[{"name":"Manitoba Firefighters Burn Unit, Health Sciences Centre, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin P.","family":"Gawaziuk","sequence":"additional","affiliation":[{"name":"Manitoba Firefighters Burn Unit, Health Sciences Centre, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeenib","family":"Kohja","sequence":"additional","affiliation":[{"name":"College of Medicine, BSc (Med Research Program, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1389-0527","authenticated-orcid":false,"given":"Sarvesh","family":"Logsetty","sequence":"additional","affiliation":[{"name":"Manitoba Firefighters Burn Unit, Health Sciences Centre, Winnipeg, Manitoba, Canada"},{"name":"Department of Psychiatry, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Surgery, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"bibr1-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-016-0097-y"},{"key":"bibr2-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2007.04.023"},{"key":"bibr3-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199505000-00013"},{"key":"bibr4-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e318239d571"},{"key":"bibr5-22925503211034830","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2014.00036"},{"key":"bibr6-22925503211034830","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200308000-00005"},{"key":"bibr7-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1097\/01.mej.0000228447.48276.7b"},{"key":"bibr8-22925503211034830","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2700.173868"},{"key":"bibr9-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000513"},{"key":"bibr10-22925503211034830","first-page":"1","volume":"8","author":"Khamnuan P","year":"2015","journal-title":"Risk Manag Healthc Policy"},{"key":"bibr11-22925503211034830","volume":"2015","author":"Oud L","year":"2015","journal-title":"Crit Care Res Pract"},{"key":"bibr12-22925503211034830","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318220d7fa"},{"key":"bibr13-22925503211034830","unstructured":"Council for Continuing Pharmaceutical Education. 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