{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:17:30Z","timestamp":1778555850894,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Plast Surg (Oakv)"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Non-surgical rhinoplasty with hyaluronic acid (HA) filler is a three-dimensional reshaping technique that achieves tissue enhancement by placing HA deep to nasal skin. Due to its unique rheology, Restylane\u00ae Lyft (HA-L, Galderma, Uppsala, Sweden) may be particularly well-suited for injection rhinoplasty, as it has high gel firmness (G\u2019) for strong structural support with minimal integration propensity.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A prospective clinical trial was conducted to evaluate HA-L use for non-surgical rhinoplasty. Thirty-three females were observed over eight months, using the following schedule: Visit 1\u2009=\u2009Baseline\/Treatment 1; Visit 2\u2009=\u2009Optional touch up (Week 2); Visits 3\u20136\u2009=\u2009Follow-ups (Months 1,3,6,8). The primary endpoint was subject improvement at Month 1 assessed by a blinded evaluator using the Global Aesthetic Improvement Scale (GAIS). Subject satisfaction and adverse events (AEs) were also evaluated.\n                    <jats:bold>Results:<\/jats:bold>\n                    A deep, periosteal injection using a bolus technique and 0.34 cc of HA-L was most often used. Seven cases of positive aspiration occurred in 167 injection points (4.19%), among 6\/33 (18.18%) subjects. Based on the GAIS, 100% of subjects met the primary endpoint. Subject satisfaction was maximal at Month 1 (100%) and largely maintained at Month 8 (78.57%). Besides expected injection-related AEs (eg, ecchymosis, erythema), immediate AEs during\/following treatment were limited to presyncopal symptoms [5\/33 subjects (15.15%)]. Importantly, no cases of ischemia were observed. Subject-reported AEs (eg, swelling, erythema, pain) dissipated within 2 to 7 days.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Given the technical nature of this technique, HA-L may be well-suited for injection rhinoplasty, due to its strong safety and efficacy profile.\n                    <jats:bold>Level of Evidence:<\/jats:bold>\n                    Level III: Evidence obtained from well-designed cohort study.\n                  <\/jats:p>","DOI":"10.1177\/22925503231184263","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T15:55:51Z","timestamp":1689177351000},"page":"97-106","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A Prospective Clinical Trial Evaluating the Efficacy and Safety of Non-Animal Stabilized Hyaluronic Acid Injections for Non-Surgical Rhinoplasty"],"prefix":"10.1177","volume":"33","author":[{"given":"Andreas","family":"Nikolis","sequence":"first","affiliation":[{"name":"McGill University"},{"name":"Erevna Innovations Inc, Clinical Research Unit, Westmount, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-4838","authenticated-orcid":false,"given":"Kaitlyn M","family":"Enright","sequence":"additional","affiliation":[{"name":"Erevna Innovations Inc, Clinical Research Unit, Westmount, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quynh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Erevna Innovations Inc, Clinical Research Unit, Westmount, Quebec, Canada"},{"name":"Universit\u00e9 de Montr\u00e9al"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani H.","family":"Sinno","sequence":"additional","affiliation":[{"name":"McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-6566","authenticated-orcid":false,"given":"Sebastian","family":"Cotofana","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.06.020"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14173"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-019-01538-8"},{"key":"e_1_3_2_5_2","unstructured":"American Society of Plastic Surgeons. 2018 Plastic Surgery Statistics Report. https:\/\/www.plasticsurgery.org\/documents\/News\/Statistics\/2018\/plastic-surgery-statistics-full-report-2018.pdf. Accessed January 15 2023."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000198549.64341.17"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4236\/jcdsa.2018.82008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005429"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy005"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29150.x"},{"key":"e_1_3_2_11_2","unstructured":"Galderma. Restylane\u00ae Lyft Lidocaine. Instructions for Use. November 2016."},{"key":"e_1_3_2_12_2","unstructured":"IBM Corp. Released 2021. IBM SPSS Statistics for Windows Version 28.0. Armonk NY: IBM Corp."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13743"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002184"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12968"},{"issue":"9","key":"e_1_3_2_16_2","first-page":"37","article-title":"Vascular compromise from soft tissue augmentation: Experience with 12 cases and recommendations for optimal outcomes","volume":"7","author":"Beleznay K","unstructured":"Beleznay K, Humphrey S, Carruthers JD, Carruthers A. Vascular compromise from soft tissue augmentation: Experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol. Sep 2014;7(9):37\u201043.","journal-title":"J Clin Aesthet Dermatol"},{"issue":"2","key":"e_1_3_2_17_2","first-page":"1","article-title":"Are large diameter cannulas safe in nonsurgical rhinoplasty?","author":"Magacho-Vieira FN","year":"2023","unstructured":"Magacho-Vieira FN, Santana AP. Are large diameter cannulas safe in nonsurgical rhinoplasty? J Cosmet Dermatol. 2023(2):1\u20104.","journal-title":"J Cosmet Dermatol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13668"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojaa005"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000972"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002241"}],"container-title":["Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22925503231184263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22925503231184263","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22925503231184263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:05:24Z","timestamp":1777593924000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22925503231184263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,12]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/22925503231184263"],"URL":"https:\/\/doi.org\/10.1177\/22925503231184263","relation":{},"ISSN":["2292-5503","2292-5511"],"issn-type":[{"value":"2292-5503","type":"print"},{"value":"2292-5511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,12]]}}}