{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:44:48Z","timestamp":1783813488404,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Plast Surg (Oakv)"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Hypertrophic and keloid scars are abnormal tissue growth that can be disfiguring, for which the available treatment has not yielded consistent results. Therefore, this study aimed to evaluate the capability of Adipose tissue-derived stem cell (ADSC) therapy in treating these scars.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A literature search was conducted on PubMed, Scopus, Cochrane Library, and Web of Science from inception until July 2022. We included experimental studies that evaluated ADSCs as a therapy for hypertrophic and keloid scars in both in-vivo and in-vitro models.\n                    <jats:bold>Results:<\/jats:bold>\n                    Our findings extracted from 12 included studies demonstrated that ADSCs have a promising potential in reducing collagen deposition, proliferation, and migration rates of fibroblast, decreasing gene\/protein expression of scar-related molecules including levels of TGF-\u03b21 and lowering intracellular signal pathway-related molecules of hypertrophic and keloid scars in both models. However, no significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u2009.05) was found in the hypertrophic scar in-vitro models in terms of DCN gene expression.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Ultimately, the current studies included in this systematic review support the use of ADSCs to alleviate hypertrophic and keloid scars.\n                  <\/jats:p>","DOI":"10.1177\/22925503231195017","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:27:40Z","timestamp":1692638860000},"page":"318-328","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Adipose-Derived Stem Cell Therapy in Hypertrophic and Keloid Scars: A Systematic Review of Experimental Studies"],"prefix":"10.1177","volume":"33","author":[{"given":"Abdulrhman","family":"Khaity","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Elrazi University, Khartoum, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Albakri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The Hashemite University, Zarqa, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada Mostafa","family":"Al-dardery","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Fayoum University, Fayoum, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8359-2651","authenticated-orcid":false,"given":"Yaman A.S.","family":"Yousef","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Elrazi University, Khartoum, Sudan"},{"name":"Faculty of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-3531","authenticated-orcid":false,"given":"Jose A.","family":"Foppiani","sequence":"additional","affiliation":[{"name":"1st Faculty of Medicine, Charles University, Prague, Czech Republic"},{"name":"Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199710000-00014"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14385"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.02.011"},{"key":"e_1_3_3_6_2","unstructured":"Binic I. 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