{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:47:40Z","timestamp":1783129660968,"version":"3.54.6"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Plast Surg (Oakv)"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Lipohypertrophy is the most reported cutaneous complication of insulin injection. In cases refractory to conservative management, liposuction has been proposed as a treatment. This review aims to evaluate the use of liposuction for the treatment of insulin-induced lipohypertrophy.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A literature search was conducted to identify case reports and case series that met inclusion criteria. Demographic, procedural, and outcome data were collected and summarized.\n                    <jats:bold>Results:<\/jats:bold>\n                    Ten case reports and 1 case series met eligibility criteria; 18 patients (16 female) with a mean age of 31 years were included for analysis. The primary indication for lipectomy was cosmetic (100%), followed by pain (16.7%), injection difficulty (16.7%), and poor glycemic control (11.1%). Ten patients (55.6%) underwent general anesthesia for their procedure, while 8 (44.4%) received local anesthesia. Thighs (53.8%) were the most common anatomical site of liposuction, followed by the upper arm (19.2%), abdomen (15.4%), buttocks (7.7%), and the flank (3.8%). The median volume of adipose tissue removed per site was 300\u2005mL (range: 25-600\u2005mL), while the total volume per patient was 910.8\u2005mL (range: 200-2900\u2005mL). The average postoperative follow-up time was 5.3 months (range: 2-10 months). Three patients reported postoperative improvement of glycemic control; 100% of patients were satisfied with their procedure. Small surface irregularities were reported in 2 patients.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although future investigations are warranted, these results may indicate that the use of liposuction to treat insulin-induced lipohypertrophy is a safe and effective procedure that achieves improved cosmetics with high patient satisfaction and enhanced glycemic control.\n                  <\/jats:p>","DOI":"10.1177\/22925503231198095","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:32:21Z","timestamp":1693366341000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Insulin-Induced Lipohypertrophy Treated With Liposuction: A Review of Case Reports"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-0717","authenticated-orcid":false,"given":"Jack","family":"Mangan","sequence":"first","affiliation":[{"name":"Larner College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Levine","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Barrett","sequence":"additional","affiliation":[{"name":"Larner College of Medicine, University of Vermont, Burlington, VT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_3_2_3_2","unstructured":"US Diabetes Surveillance System. Prevalence of Diagnosed Diabetes. Accessed May 7 2022. https:\/\/www.cdc.gov\/diabetes\/data\/statistics-report\/diagnosed-diabetes."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.06.011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304100-00001"},{"key":"e_1_3_2_6_2","article-title":"Prevalence of lipohypertrophy in insulin-treated diabetes patients: a systematic review and meta-analysis","author":"Deng N","unstructured":"Deng N, Zhang X, Zhao F, Wang Y, He H. Prevalence of lipohypertrophy in insulin-treated diabetes patients: a systematic review and meta-analysis. J Diabetes Investig. 2017;9(3):536-543. doi:https:\/\/doi.org\/10.1111\/jdi.12742","journal-title":"J Diabetes Investig"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-016-0187-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.52.623"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7411.383"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.113788"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/152091501750220064"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.05.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2004.019547"},{"issue":"1","key":"e_1_3_2_14_2","article-title":"Lipohypertrophy: patient awareness and implications for practice. (Clinical Audit)","volume":"6","author":"Teft G","year":"2022","unstructured":"Teft G. Lipohypertrophy: patient awareness and implications for practice. (Clinical Audit). J Diabetes Nurs. 2022;6(1):20-23.","journal-title":"J Diabetes Nurs."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.7.5.479"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0610"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18991"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211431"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708010-00003"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1973.tb200009.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(1998120)15:12<1063::AID-DIA706>3.0.CO;2-V"},{"key":"e_1_3_2_22_2","unstructured":"American Society of Plastic Surgeons. What is liposuction? Accessed May 9 2022. https:\/\/www.plasticsurgery.org\/cosmetic-procedures\/liposuction."}],"container-title":["Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22925503231198095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22925503231198095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22925503231198095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:05:33Z","timestamp":1777593933000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22925503231198095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/22925503231198095"],"URL":"https:\/\/doi.org\/10.1177\/22925503231198095","relation":{},"ISSN":["2292-5503","2292-5511"],"issn-type":[{"value":"2292-5503","type":"print"},{"value":"2292-5511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]}}}