{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:38:01Z","timestamp":1777880281765,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Plast Surg (Oakv)"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Dupuytren disease (DD) is a fibroproliferative disorder characterized by excess collagen deposition in the digitopalmar fascia resulting in disabling flexion contractures. The angiotensin II type 1 receptor (AT1R) pathway has previously been shown to be upregulated in a variety of other fibrotic disorders. We explored the potential association between DD and activating autoantibodies (AAb) against the profibrotic AT1R or counterregulatory antifibrotic angiotensin II type 2 receptor (AT2R).\n                    <jats:bold>Methods:<\/jats:bold>\n                    Patients with DD and controls were recruited from a single hand clinic. Demographic and clinical data and total flexion deformity angle of each digit were recorded. Serum levels of AT1R-AAb and AT2R-AAb were measured by enzyme-linked immunosorbent assay.\n                    <jats:bold>Results:<\/jats:bold>\n                    No differences were noted in serum AT1R-AAb levels between control and DD patients. In women with DD, circulating AT2R-AAb were significantly lower than in control women (7.61\u2009\u00b1\u20093.0\u2005U\/mL vs 13.5\u2009\u00b1\u20093.1\u2005U\/mL, respectively). AT2R-AAb observed values tended to be lower in women with higher Tubiana severity scores. In contrast, AT2R-AAb levels were not different between control or DD male subjects.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    These early findings suggest angiotensin II signaling differences may contribute to sex differences in DD and that an AT2R agonist may be particularly beneficial in treating women with DD.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Diagnostic, Level II.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/22925503251344305","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T03:29:33Z","timestamp":1749094173000},"page":"259-265","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin Receptor Autoantibodies in Dupuytren Disease: A Biomarker Study"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-9037","authenticated-orcid":false,"given":"Natasha D.","family":"Osborne","sequence":"first","affiliation":[{"name":"Dalhousie University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5973-7407","authenticated-orcid":false,"given":"Julia M.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tang","sequence":"additional","affiliation":[{"name":"University of British Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadim G.","family":"Joukhadar","sequence":"additional","affiliation":[{"name":"Dalhousie University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-5147","authenticated-orcid":false,"given":"Michael","family":"Bezuhly","sequence":"additional","affiliation":[{"name":"Dalhousie University"},{"name":"Dalhousie University"},{"name":"Division of Plastic Surgery, IWK Health Centre, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.180"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-015-0476-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-007-9076-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13069-015-0023-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.04.005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135772"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-012-9410-z"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i48.7560"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12397"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15571"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000436927.08026.a8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2020.12.003"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035717"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00249-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0379TR"},{"issue":"7","key":"e_1_3_3_17_2","article-title":"Embryonic stem cell-like population in Dupuytren\u2019s disease expresses components of the renin-angiotensin system","volume":"5","author":"On N","year":"2017","unstructured":"On N, Koh SP, Brasch HD, et al. Embryonic stem cell-like population in Dupuytren\u2019s disease expresses components of the renin-angiotensin system. Plast Reconstr Surg Glob Open. 2017;5(7):e1422. doi:https:\/\/doi.org\/10.1097\/GOX.0000000000001422","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003800"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/2000656X.2017.1319846"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11552-007-9071-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2010.00854.x"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05428"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1470320312466519"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2006.09.006"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0712(21)00439-X"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.03.008"}],"container-title":["Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22925503251344305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/22925503251344305","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/22925503251344305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:06:50Z","timestamp":1777594010000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/22925503251344305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/22925503251344305"],"URL":"https:\/\/doi.org\/10.1177\/22925503251344305","relation":{},"ISSN":["2292-5503","2292-5511"],"issn-type":[{"value":"2292-5503","type":"print"},{"value":"2292-5511","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}