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Within 2 years she had rapid polyethylene wear with aggressive, asymptomatic, and periprosthetic osteolysis on both sides. Oral alendronate therapy halted the progression of osteolysis over a year and revision to cross-linked polyethylene liners was then undertaken while one stem was curettaged and the other revised. Radiostereometric analysis revealed a 96% reduction in wear rate over 2 years with the cross-linked liners. On stopping alendronate treatment, aggressive osteolysis recurred on the curretaged but not on the revised femur.<\/jats:p>","DOI":"10.1177\/230949900401200121","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T17:14:58Z","timestamp":1475601298000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cross-Linked Polyethylene and Bisphosphonate Therapy for Osteolysis in Total Hip Arthroplasty: A Case Report"],"prefix":"10.1177","volume":"12","author":[{"given":"LJ","family":"O'Hara","sequence":"first","affiliation":[{"name":"Perth Orthopaedic Institute, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Nivbrant","sequence":"additional","affiliation":[{"name":"Perth Orthopaedic Institute, Western Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"R\u00f6hrl","sequence":"additional","affiliation":[{"name":"Consultant Orthopaedic Surgeon, University Hospital Umea, Umea, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"bibr1-230949900401200121","first-page":"46","volume":"311","author":"Harris WH","year":"1995","journal-title":"Clin Orthop"},{"key":"bibr2-230949900401200121","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100180110"},{"key":"bibr3-230949900401200121","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100170203"},{"key":"bibr4-230949900401200121","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.78B2.0780280"},{"key":"bibr5-230949900401200121","doi-asserted-by":"publisher","DOI":"10.3109\/17453679608994677"},{"key":"bibr6-230949900401200121","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200202000-00011"},{"key":"bibr7-230949900401200121","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200100022-00009"},{"key":"bibr8-230949900401200121","unstructured":"Nivbrant B. 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