{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:40:59Z","timestamp":1777880459987,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To study high-energy phosphates in cortical bone through experiments on inbred white New Zealand rabbits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Tibial fractures were induced in 80 rabbits and then stabilised by screw osteosynthesis. After 3 (group A; n=40) or 7 days (groups B; n=40), the defective tissue was covered by local muscle flaps. At increasing intervals (from 1 to 16 weeks), the screws were removed and the animals were euthanised (n=8 per group). The bone was removed and analysed histomorphologically; adenosine triphosphate (ATP) levels were determined by high-performance liquid chromatography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The mean ATP concentration in healthy cortical bone at 16 weeks was 0.092 (standard error, 0.009) nmol\/mg dry mass, which was significantly higher than that in the group with delayed healing: 0.081 (0.011) nmol\/mg in group A and 0.005 (0.001) nmol\/mg in group B (paired t test, p&lt;0.05). Earlier healing led to lower rates of necrosis (0 vs 38; groups A vs B) and osteomyelitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Early muscle-flap coverage can revascularise the cortical bone, which is reflected in the higher ATP content in the cortical bone measured by high-performance liquid chromatography. Measuring changes of ATP levels can help investigate the metabolism of the pathological bone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/230949900401200213","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T17:14:58Z","timestamp":1475601298000},"page":"205-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of High-Energy Phosphates in Cortical Bone as an Indicator of Bone Healing and Remodelling: Use of a Rabbit Model"],"prefix":"10.1177","volume":"12","author":[{"given":"J","family":"Buchholz","sequence":"first","affiliation":[{"name":"Surgical Clinic Wermelskirchen, Wermelskirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FX","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PJ","family":"Meeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Muhr","sequence":"additional","affiliation":[{"name":"Trauma Center Bergmannsheil, Bochum University, Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GK","family":"Kreitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Herzog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,12,1]]},"reference":[{"key":"bibr1-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650030315"},{"key":"bibr2-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197510000-00005"},{"key":"bibr3-230949900401200213","volume-title":"Statistical methods for engineers and scientists","author":"Bethea R","year":"1985"},{"key":"bibr4-230949900401200213","volume-title":"Statistische Formeln, Tabellen und Programme","author":"Bleym\u00fcller J","year":"1988"},{"key":"bibr5-230949900401200213","volume-title":"Guide for the care and use of laboratory animals","author":"United States National Institutes of Health","year":"1985"},{"key":"bibr6-230949900401200213","volume-title":"Protocol of the Society for Laboratory Animal Science (GV-SOLAS protocol)","year":"1986"},{"key":"bibr7-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1159\/000267000"},{"key":"bibr8-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1080\/00365519009089169"},{"key":"bibr9-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.8.64"},{"key":"bibr10-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1995.1164"},{"key":"bibr11-230949900401200213","first-page":"167","volume":"60","author":"Valka J","year":"1993","journal-title":"Acta Chir Orthop Traumatol Cech"},{"key":"bibr12-230949900401200213","first-page":"875","volume":"108","author":"Wissing H","year":"1983","journal-title":"Zentralbl Chir"},{"key":"bibr13-230949900401200213","first-page":"S83","volume":"74","author":"Gerlach E","year":"1985","journal-title":"Z Kardiol"},{"key":"bibr14-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.6.1087"},{"key":"bibr15-230949900401200213","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-02480-5"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949900401200213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949900401200213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:12:10Z","timestamp":1777594330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/230949900401200213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1177\/230949900401200213"],"URL":"https:\/\/doi.org\/10.1177\/230949900401200213","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}