{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:51:10Z","timestamp":1779216670233,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To review and evaluate the management of 14 patients with pyogenic vertebral osteomyelitis at National University Hospital, Singapore between 1998 and 2001.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Demographic pattern, predisposing factors, clinical presentation, co-morbidities, microbiology, treatment, and complications of 14 patients were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>The mean age at presentation was 62.5 years and the male to female ratio was 6:1. The mean follow-up duration was 12.5 months. The most common predisposing condition was diabetes mellitus (n=5). The most common site of infection was the lumbar spine (n=8), followed by the thoracic (n=4) and cervical (n=2) spine. Staphylococcus aureus was the most common causative organism isolated (n=9), followed by methicillin-resistant S aureus (n=3), Pseudomonas pseudomallei (n=1), and Streptococcus agalactiae (n=1). 12 patients were treated surgically: 8 by an anterior approach, 3 by a posterior approach, and one by a combination of the 2. The mean period of antibiotic use was 11.4 weeks. One patient with melioidosis involving the T9 to T11 vertebrae caused by P pseudomallei died of empyema and septicaemia 22 months after presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Pyogenic vertebral osteomyelitis is not uncommon in the elderly, especially those with predisposing conditions such as diabetes mellitus. Computed tomography\u2013guided needle biopsy is recommended to investigate causative micro-organisms. Aggressive surgical debridement and prolonged antibiotic therapy were necessary in patients with methicillin-resistant S aureus, P pseudomallei, and S agalactiae.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/230949900501300305","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T17:14:58Z","timestamp":1475601298000},"page":"240-244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Pyogenic Vertebral Osteomyelitis: A Review of 14 Cases"],"prefix":"10.1177","volume":"13","author":[{"given":"A","family":"Nather","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, National University Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"David","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, National University Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HT","family":"Hee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, National University Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Thambiah","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, National University Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2005,12,1]]},"reference":[{"key":"bibr1-230949900501300305","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/00365540110026566","volume":"33","author":"Beronius M","year":"2001","journal-title":"Scand J Infect Dis"},{"key":"bibr2-230949900501300305","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199706000-00011"},{"key":"bibr3-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.61B1.370121"},{"key":"bibr4-230949900501300305","first-page":"429","volume":"42","author":"Garcia A","year":"1960","journal-title":"Am J Orthop"},{"key":"bibr5-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1007\/s005860050027"},{"key":"bibr6-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1097\/00024720-200204000-00004"},{"key":"bibr7-230949900501300305","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198365010-00004"},{"key":"bibr8-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.53B3.383"},{"key":"bibr9-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)32053-8"},{"key":"bibr10-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.2.320"},{"key":"bibr11-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200007010-00010"},{"key":"bibr12-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)32045-9"},{"key":"bibr13-230949900501300305","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.6.0878"},{"key":"bibr14-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1086\/340102"},{"key":"bibr15-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199605000-00013"},{"key":"bibr16-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1097\/00024720-200204000-00010"},{"key":"bibr17-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199905000-00047"},{"key":"bibr18-230949900501300305","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00003086-199007000-00015","volume":"256","author":"Fasano FJ","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"bibr19-230949900501300305","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0694"},{"key":"bibr20-230949900501300305","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199312000-00011"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949900501300305","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949900501300305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:12:41Z","timestamp":1777594361000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/230949900501300305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1177\/230949900501300305"],"URL":"https:\/\/doi.org\/10.1177\/230949900501300305","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}