{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:53:57Z","timestamp":1781686437674,"version":"3.54.5"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To identify factors predicting one-year mortality in patients on clopidogrel presenting with proximal femoral fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>9 men and 22 women aged 64 to 97 (mean, 81; standard deviation, 8) years who had been taking clopidogrel for ischaemic heart disease (n=15), cerebrovascular disease (n=6), or both (n=10) presented with proximal femoral fractures. The time from injury to operation, type of anaesthesia, treatment method, and postoperative complications were reviewed. One-year mortality was analysed using the Kaplan-Meier curve. Factors predicting one-year mortality were identified. Results. The fracture configurations of the 31 patients included intracapsular femoral neck fracture (n=17), intertrochanteric fracture (n=13), and subtrochanteric fracture (n=1). 30 of the patients underwent hemiarthroplasty (n=16), dynamic hip screw fixation (n=9) or intramedullary hip screw fixation (n=5). The remaining patient underwent conservative treatment owing to metastatic prostate cancer. Of the 30 patients who underwent surgery, clopidogrel was discontinued at least 7 days prior to surgery, with the mean delay to surgery being 8.4 (range, 2\u201316) days. No patient had excessive blood loss at operation, although 7 patients received a blood transfusion postoperatively. 13 (43%) patients developed postoperative complications. The one-year mortality was 26% (8\/31). Univariate analysis showed that factors predicting one-year mortality were spinal anaesthesia (p=0.04), postoperative blood transfusion (p=0.03), postoperative complications (p=0.03), and delay to surgery (p=0.03). Multiple regression analysis showed that delay to surgery (p=0.03) was the only independent predictor of one-year mortality, with a hazard ratio of 1.357 (95% confidence interval, 1.03\u20131.79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Surgery should be performed as soon as possible in medically fit patients having proximal femoral fractures who are taking clopidogrel, as delay to surgery is associated with increased one-year mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/230949901101900310","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T17:16:28Z","timestamp":1475601388000},"page":"314-316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":28,"title":["Factors Influencing Mortality in Patients on Antiplatelet Agents Presenting with Proximal Femoral Fractures"],"prefix":"10.1177","volume":"19","author":[{"given":"Rohit","family":"Maheshwari","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehool","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Monda","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakant","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,12,1]]},"reference":[{"key":"bibr1-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/23.1.11"},{"key":"bibr2-230949901101900310","unstructured":"NICE guidelines. Clopidogrel and modified-release dipyridimole in the prevention of occlusive vascular events. May 2005."},{"key":"bibr3-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1177\/107602969600200108"},{"key":"bibr4-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.01.011"},{"key":"bibr5-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2007.05.014"},{"key":"bibr6-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-5-6"},{"key":"bibr7-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0503300608"},{"key":"bibr8-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1007\/BF02942060"},{"key":"bibr9-230949901101900310","first-page":"CD000521","volume":"4","author":"Parker MJ","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr10-230949901101900310","doi-asserted-by":"publisher","DOI":"10.1097\/01.bot.0000249435.25751.e8"},{"key":"bibr11-230949901101900310","first-page":"11","volume":"5","author":"Association of Anaesthetists of Great Britain and Ireland","journal-title":"Section"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949901101900310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949901101900310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:17:39Z","timestamp":1777594659000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/230949901101900310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1177\/230949901101900310"],"URL":"https:\/\/doi.org\/10.1177\/230949901101900310","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}