{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:02:21Z","timestamp":1784606541092,"version":"3.55.0"},"reference-count":13,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose.<\/jats:title>\n                    <jats:p>To determine the risk factors for recurrence of giant cell tumours (GCTs) of bone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>Medical records of 29 men and 29 women (mean age, 34 years) treated for primary (n=53) or recurrent (n=5) GCTs of bone and followed up for a mean of 40.2 months were reviewed. The tumours were located in the distal femur (n=18), proximal tibia (n=10), proximal femur (n=8), distal radius (n=7), proximal fibula (n=4), distal ulna (n=3), calcaneum (n=3), sacrum (n=2), vertebra (n=1), metatarsal (n=1), and distal humerus (n=1). 26 patients had pathological fractures, 12 had cortical break, and 20 had neither. The Campanacci grades of the tumours were I (n=1), II (n=18), and III (n=33); the grades of the remaining 6 tumours were unknown because radiographs were unavailable. The Enneking stages of the tumours were 1 (n=51), 2 (n=6), and 3 (n=1). Treatment included curettage and cementation (n=29), curettage, cementation, and adjuvant treatment with distilled water or liquid nitrogen for bones without fracture (n=18), wide resection for extensive soft tissue involvement (n=9), and amputation (n=2) for a recurrent GCT of the distal femur and a primary GCT of the calcaneus. Reconstruction included cementation (n=27), bone grafting (n=7), cementation\/bone grafting with internal fixation (n=14), reconstruction with endoprosthesis (n=3), and none (n=7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>19 patients had recurrence after a mean of 23.1 months. The overall recurrence-free survival at years 1, 2, and 3 were 86%, 79%, and 72%, respectively. Recurrence did not correlate with patient age (p=0.20), primary or recurrent tumour at presentation (p=0.12), Campanacci grade (p=0.10), Enneking stage (p=0.54), or presence of pathological fracture (p=0.28). Compared to GCTs at other locations, GCTs in the proximal tibia were more likely to recur (27% vs. 60%, p=0.04).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>GCTs of the proximal tibia are more likely to recur than those at other locations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/230949901402200127","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T17:13:55Z","timestamp":1475601235000},"page":"108-110","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Risk Factors for Recurrence of Giant Cell Tumours of Bone"],"prefix":"10.1177","volume":"22","author":[{"given":"Mashfiqul A","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chusheng","family":"Seng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mann Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"bibr1-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200204000-00030"},{"key":"bibr2-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199602000-00008"},{"key":"bibr3-230949901402200127","doi-asserted-by":"crossref","first-page":"235","DOI":"10.47102\/annals-acadmedsg.V34N3p235","volume":"34","author":"Lim YW","year":"2005","journal-title":"Ann Acad Med Singapore"},{"key":"bibr4-230949901402200127","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198264050-00015"},{"key":"bibr5-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0370-x"},{"key":"bibr6-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1080\/17453670710014815"},{"key":"bibr7-230949901402200127","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199906000-00008"},{"key":"bibr8-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-003-0562-4"},{"key":"bibr9-230949901402200127","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198769010-00018"},{"key":"bibr10-230949901402200127","first-page":"87","volume-title":"musculoskeletal tumor surgery","author":"Enneking WF","year":"1983"},{"key":"bibr11-230949901402200127","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.D.02771"},{"key":"bibr12-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200012000-00022"},{"key":"bibr13-230949901402200127","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199712000-00021"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949901402200127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/230949901402200127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:19:56Z","timestamp":1777594796000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/230949901402200127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1177\/230949901402200127"],"URL":"https:\/\/doi.org\/10.1177\/230949901402200127","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4]]}}}