{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T07:47:05Z","timestamp":1777880825318,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:p>Diffuse-type tenosynovial giant cell tumor (TS-GCT) is categorized as a locally aggressive but non-metastasizing neoplasm according to the WHO classification. Herein, we report an extremely rare case of a 41-year-old woman who developed multiple metastases from diffuse TS-GCT with benign histological features. The patient complained of a painful buttock mass and imaging studies revealed a soft tissue tumor of the buttock and multiple pulmonary nodules. The buttock tumor was excised and the final diagnosis was extra-articular diffuse-type TS-GCT. By video-assisted thoracic surgery, pulmonary nodules were pathologically identical to the primary tumor. Residual pulmonary nodules progressively grew, and she developed a muscle metastasis and a subcutis metastasis. She died of respiratory dysfunction due to multiple pulmonary metastases 1 year after primary surgery. Very few reports on histologically benign metastases from TS-GCT have been published, and the natural course of this rare condition remains unclarified. This rare case could provide important information for further clinical evaluation of this tumor.<\/jats:p>","DOI":"10.1177\/2309499017690323","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T01:02:44Z","timestamp":1487638964000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Extra-articular diffuse-type tenosynovial giant cell tumor with benign histological features resulting in fatal pulmonary metastases"],"prefix":"10.1177","volume":"25","author":[{"given":"Toshihisa","family":"Osanai","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hiraga","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"bibr1-2309499017690323","first-page":"766","volume-title":"Enzinger and Weiss\u2019s soft tissue tumours","author":"Goldblum JR","year":"2013","edition":"6"},{"key":"bibr2-2309499017690323","first-page":"102","volume-title":"WHO classification of tumours of soft tissue and bone","author":"Somerhausen NS","year":"2013","edition":"4"},{"key":"bibr3-2309499017690323","doi-asserted-by":"publisher","DOI":"10.3109\/17453679508994643"},{"key":"bibr4-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200004000-00002"},{"key":"bibr5-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-013-0267-8"},{"key":"bibr6-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.06.025"},{"key":"bibr7-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1186\/s13569-015-0030-2"},{"key":"bibr8-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.11.001"},{"key":"bibr9-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199702000-00004"},{"key":"bibr10-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318158428f"},{"key":"bibr11-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.94B7.28927"},{"key":"bibr12-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.97B4.34907"},{"key":"bibr13-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507321103"},{"key":"bibr14-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn033"},{"key":"bibr15-2309499017690323","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26409"}],"container-title":["Journal of Orthopaedic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2309499017690323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2309499017690323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2309499017690323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:23:08Z","timestamp":1777594988000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2309499017690323"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,1]]}},"alternative-id":["10.1177\/2309499017690323"],"URL":"https:\/\/doi.org\/10.1177\/2309499017690323","relation":{},"ISSN":["1022-5536","2309-4990"],"issn-type":[{"value":"1022-5536","type":"print"},{"value":"2309-4990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,1]]},"article-number":"2309499017690323"}}