{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T10:00:37Z","timestamp":1782554437202,"version":"3.54.5"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Orthop Surg (Hong Kong)"],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Investigation of the expression of platelet-derived growth factor (PDGF)-\u03b2 and glial fibrillary acidic protein (GFAP) in rats with spinal cord injury as a marker of neurologic recovery between groups treated with erythropoietin (EPO) and methylprednisolone (MP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty adult female rats were randomly divided into three even groups. A laminectomy was applied to thoracic ninth vertebra and contusion injury was induced by extradural application of an aneurysm clip. Group 1 rats received one-time intrathecal administration of normal saline, group 2 rats received MP, and group 3 rats received EPO. Motor neurological function was evaluated by the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale. Thirty days after the surgery, T8\u201310 segments of the spinal cords were extracted and the immunohistochemical assay revealed the number of PDGF-\u03b2- and GFAP-positive cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Evaluation of the last control animal showed that BBB score in the EPO group showed an increase from 1 to 12 ( p &lt; 0.05). The immunohistochemical assay revealed that the number of PDGF-\u03b2- and GFAP-positive cells was significantly higher in EPO group ( p = 0.000) when compared to MP and control groups. After studying the effect of PDGF-\u03b2 expression on the locomotor function, we determined that PDGF-\u03b2 expression and locomotor function after a spinal injury has a strong relationship ( p &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>EPO seems to better increase the expression of PDGF-\u03b2, thus produce better results in locomotor functions when compared to MP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2309499017739481","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T23:23:55Z","timestamp":1510269835000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigation of efficacy of treatment in spinal cord injury: Erythropoietin versus methylprednisolone"],"prefix":"10.1177","volume":"25","author":[{"given":"Okan","family":"Ozkunt","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, Acibadem University Atakent Hospital, Halkali\/Kucukcekmece, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim","family":"Sariyilmaz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Acibadem University Atakent Hospital, Halkali\/Kucukcekmece, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil Can","family":"Gemalmaz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Acibadem University Atakent Hospital, Halkali\/Kucukcekmece, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seren G\u00fclsen","family":"G\u00fcrgen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Celal Bayar University School of Vocational Health Service, Yunusemre, Manisa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ula\u015f","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Acibadem University Atakent Hospital, Halkali\/Kucukcekmece, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Dikici","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Acibadem University Atakent Hospital, Halkali\/Kucukcekmece, Istanbul, 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