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We report the rare case of a multiparous woman with a spontaneous conception resulting in a triplet heterotopic pregnancy: a twin intrauterine pregnancy and a single right tubal ectopic pregnancy. Heterotopic pregnancy is a rare and potentially life-threatening condition in which simultaneous gestations occur at 2 or more implantation sites. It is infrequent in natural conception cycles, occurring in 1:30 000 pregnancies. However, the prevalence is rising with the increased use of assisted reproduction techniques to that of 1:100 to 1:500 in these patient subgroups, highlighting the need to incorporate it into a clinician\u2019s diagnostic algorithm.<\/jats:p>","DOI":"10.1177\/2324709614531556","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T01:29:11Z","timestamp":1397698151000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Spontaneous Heterotopic Triplet Pregnancy With Tubal Rupture"],"prefix":"10.1177","volume":"2","author":[{"given":"Lima","family":"Arsala","sequence":"first","affiliation":[{"name":"Royal Women\u2019s Hospital, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Danso","sequence":"additional","affiliation":[{"name":"Latrobe Regional Hospital, Traralgon, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,16]]},"reference":[{"key":"bibr1-2324709614531556","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2010.522749"},{"key":"bibr2-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00154-9"},{"key":"bibr3-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(99)00079-2"},{"key":"bibr4-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(92)90128-K"},{"key":"bibr5-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58378-2"},{"key":"bibr6-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.103620"},{"key":"bibr7-2324709614531556","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.39595"},{"key":"bibr8-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00921.x"},{"key":"bibr9-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.7.1999"},{"key":"bibr10-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00441-5"},{"key":"bibr11-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136125"},{"key":"bibr12-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12341"},{"key":"bibr13-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138247"},{"key":"bibr14-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-2-9369"},{"key":"bibr15-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1577-z"},{"key":"bibr16-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56155-X"},{"key":"bibr17-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000175145.23512.5e"},{"key":"bibr18-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1080\/00016340600617486"},{"key":"bibr19-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.192"},{"key":"bibr20-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.12.030"},{"key":"bibr21-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.06.037"},{"key":"bibr22-2324709614531556","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.085"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709614531556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709614531556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709614531556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:05:02Z","timestamp":1777449902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709614531556"}},"subtitle":["A Case Report and Literature Review"],"short-title":[],"issued":{"date-parts":[[2014,4,16]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6,1]]}},"alternative-id":["10.1177\/2324709614531556"],"URL":"https:\/\/doi.org\/10.1177\/2324709614531556","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,16]]},"article-number":"2324709614531556"}}