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We report a child with Diamond-Blackfan anemia who has significant complications from iron overload due to chronic blood transfusion, and one of these complications is acquired platelet function defect that manifests with frequent episodes of epistaxis. Therefore, we emphasize the necessity for further studies to confirm direct correlation between iron overload as a causative agent and platelets dysfunction. And we recommend screening for platelets function in patients receiving chronic blood transfusion aiming at possible prevention of any life-threatening bleeding.<\/jats:p>","DOI":"10.1177\/2324709616675645","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T21:40:58Z","timestamp":1477518058000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Iron Overload and Platelet Function Defects"],"prefix":"10.1177","volume":"4","author":[{"given":"Abdulkader A.","family":"Dahi","sequence":"first","affiliation":[{"name":"King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab","family":"Hanafy","sequence":"additional","affiliation":[{"name":"King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al Pakra","sequence":"additional","affiliation":[{"name":"King Salman Armed Forces Hospital, Tabuk, Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"bibr1-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-370098"},{"key":"bibr2-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02551.x"},{"key":"bibr3-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1038\/nm1629"},{"key":"bibr4-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1002\/9780470696705"},{"key":"bibr5-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20685"},{"key":"bibr6-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1004810"},{"key":"bibr7-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2014.04.004"},{"key":"bibr8-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12825"},{"key":"bibr9-2324709616675645","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1055\/s-0037-1617178","volume":"28","author":"Scharf RE","year":"2008","journal-title":"Hamostaseologie"},{"key":"bibr10-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1177\/00912700022008766"},{"key":"bibr11-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.08.002"},{"key":"bibr12-2324709616675645","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12053"},{"key":"bibr13-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1984.tb00730.x"},{"key":"bibr14-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-976169"},{"key":"bibr15-2324709616675645","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1542\/peds.68.2.238","volume":"68","author":"Buchanan GR","year":"1981","journal-title":"Pediatrics"},{"key":"bibr16-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00693.x"},{"key":"bibr17-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147228.29325.F9"},{"key":"bibr18-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04052.x"},{"key":"bibr19-2324709616675645","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000287"},{"key":"bibr20-2324709616675645","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2011.634933"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709616675645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709616675645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709616675645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:59:12Z","timestamp":1777449552000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709616675645"}},"subtitle":["Possible Correlation"],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1177\/2324709616675645"],"URL":"https:\/\/doi.org\/10.1177\/2324709616675645","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]},"article-number":"2324709616675645"}}