{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:31:54Z","timestamp":1777671114045,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Rituximab (R), a chimeric monoclonal antibody targeting CD20 antigen on B-cells, has become a standard of care in the treatment of B-cell malignancies, most often in conjunction with cytotoxic chemotherapy. Activity has been demonstrated in many subtypes of B-cell lymphoma, including diffuse large cell lymphoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), lymphocyte-predominant Hodgkin lymphoma, and Waldenstr\u00f6m macroglobulinemia (WM). Additionally, dose escalation of R as a single agent has demonstrated improved activity in previously treated\/poor prognosis CLL. We present 4 cases of B-cell malignancy (2 CLL variants\/MCL, 1 FL, 1 WM) who received dose-escalated R as a single agent and achieved complete response (3 patients) and stable disease\/partial response (1 patient) of 6.5+ to 15+ years duration. They have been off treatment for 6.5+ to 15+ years. Toxicity was minimal, with initial infusion reactions similar to those observed with standard dose infusions. There were no serious treatment-related adverse events or infections. Dose escalated R as a single agent may possibly be curative for some patients with B-cell malignancies, unlike the standard empiric dose of 375 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , and deserves further study.\n                  <\/jats:p>","DOI":"10.1177\/2324709617691307","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T08:16:51Z","timestamp":1486455411000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Response and Possible Cure of Patients With B-Cell Malignancies With Dose-Escalated Rituximab"],"prefix":"10.1177","volume":"5","author":[{"given":"Lauren M.","family":"Jacobs","sequence":"first","affiliation":[{"name":"George Washington University, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H.","family":"Wiernik","sequence":"additional","affiliation":[{"name":"Cancer Research Foundation of New York, Chappaqua, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice P.","family":"Dutcher","sequence":"additional","affiliation":[{"name":"Cancer Research Foundation of New York, Chappaqua, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Muxi","sequence":"additional","affiliation":[{"name":"British Hospital, Montevideo, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"key":"bibr1-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"bibr2-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14232"},{"key":"bibr3-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2825"},{"key":"bibr4-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.3968"},{"key":"bibr5-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61763-2"},{"key":"bibr6-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.63.5904"},{"key":"bibr7-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200920"},{"key":"bibr8-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-304683"},{"key":"bibr9-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-583765"},{"key":"bibr10-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2165"},{"key":"bibr11-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.615307"},{"key":"bibr12-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.2069"},{"key":"bibr13-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08750.x"},{"key":"bibr14-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0126"},{"key":"bibr15-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-553974"},{"key":"bibr16-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701724785"},{"key":"bibr17-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1177\/107327480100802S01"},{"key":"bibr18-2324709617691307","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830400404"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709617691307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709617691307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709617691307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:59:17Z","timestamp":1777449557000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709617691307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1177\/2324709617691307"],"URL":"https:\/\/doi.org\/10.1177\/2324709617691307","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"article-number":"2324709617691307"}}