{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:33:37Z","timestamp":1777671217149,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>The relationship between reactive arthritis and enteric infections caused by Yersinia enterocolitica, Campylobacter jejuni, and Salmonella typhimurium is well documented. Clostridium difficile colitis is a less recognized cause of reactive arthritis. We present a case of a 58-year-old woman with Clostridium difficile colitis complicated by reactive arthritis. A 58-year-old woman with no significant past medical history presented to our hospital with complaints of nonbloody watery diarrhea, abdominal pain for the past 1 week, and right knee pain starting 1 day prior. The patient had recently used antibiotics for a respiratory tract infection. On examination, the patient had a swollen and erythematous right knee. While in the hospital the patient also developed a similarly painful and swollen left knee. The patient was found to be positive for C difficile toxin in stool. Synovial fluid analysis of both the knee joints revealed a sterile and inflammatory fluid, negative for crystals and showing no growth on gram stain. We diagnosed the patient with reactive arthritis secondary to C difficile colitis once all other causes of the bilateral knee joint symptoms were ruled out with appropriate laboratory and imaging studies. Treatment with oral vancomycin and an anti-inflammatory was initiated, and the patient had complete resolution of symptoms. This case illustrates the importance of recognizing C difficile colitis as a potential differential for reactive arthritis under the appropriate circumstances. The treatment of reactive arthritis is mainly supportive and treating the underlying cause, which happens to be C difficile in this case.<\/jats:p>","DOI":"10.1177\/2324709618767689","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T05:57:41Z","timestamp":1522389461000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Clostridium difficile<\/i>\n                    Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease"],"prefix":"10.1177","volume":"6","author":[{"given":"Asghar","family":"Marwat","sequence":"first","affiliation":[{"name":"Temple University, Philadelphia, PA, USA"},{"name":"Conemaugh Memorial Medical Center, Johnstown, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-4913","authenticated-orcid":false,"given":"Hassan","family":"Mehmood","sequence":"additional","affiliation":[{"name":"Temple University, Philadelphia, PA, USA"},{"name":"Conemaugh Memorial Medical Center, Johnstown, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Hussain","sequence":"additional","affiliation":[{"name":"Temple University, Philadelphia, PA, USA"},{"name":"Conemaugh Memorial Medical Center, Johnstown, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzammil","family":"Khan","sequence":"additional","affiliation":[{"name":"Temple University, Philadelphia, PA, USA"},{"name":"Conemaugh Memorial Medical Center, Johnstown, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7400-8724","authenticated-orcid":false,"given":"Asad","family":"Ullah","sequence":"additional","affiliation":[{"name":"Temple University, Philadelphia, PA, USA"},{"name":"Conemaugh Memorial Medical Center, Johnstown, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medha","family":"Joshi","sequence":"additional","affiliation":[{"name":"Temple University, Philadelphia, PA, USA"},{"name":"Conemaugh Memorial Medical Center, Johnstown, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"bibr1-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00081-9"},{"key":"bibr2-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6942(02)00104-3"},{"key":"bibr3-2324709618767689","doi-asserted-by":"publisher","DOI":"10.3109\/rhe1.1969.15.issue-1-4.32"},{"key":"bibr4-2324709618767689","first-page":"61","volume":"162","author":"Keating RM","year":"1995","journal-title":"West J Med"},{"key":"bibr5-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2015.12.011"},{"key":"bibr6-2324709618767689","first-page":"353","volume":"65","author":"Rollins DE","year":"1976","journal-title":"Am J Gastroenterol"},{"key":"bibr7-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408913"},{"key":"bibr8-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200103000-00002"},{"key":"bibr9-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(05)80033-2"},{"key":"bibr10-2324709618767689","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1982.tb03841.x"},{"key":"bibr11-2324709618767689","first-page":"520","volume":"15","author":"Atkinson MH","year":"1988","journal-title":"J Rheumatol"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709618767689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709618767689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709618767689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:59:46Z","timestamp":1777449586000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709618767689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":11,"alternative-id":["10.1177\/2324709618767689"],"URL":"https:\/\/doi.org\/10.1177\/2324709618767689","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2324709618767689"}}