{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:33:57Z","timestamp":1777671237408,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:p>Type B lactic acidosis associated with malignancy is a life-threatening complication and mostly seen in hematological malignancies but can also be seen in solid tumors. We report a rare case of a 64-year-old female diagnosed with metastatic adenocarcinoma of the colon with liver metastasis associated with severe type B lactic acidosis. We discuss pathophysiology, previously reported cases, and their outcomes. The most widely used therapies are bicarbonate infusion, thiamine supplementation, chemotherapy, and supportive care but is associated with poor outcomes, and no standard treatment recommendations are available. Early chemotherapy administration remains the only intervention that has shown some survival benefit. Physicians should be aware and proactive for early diagnosis and management of this condition with further research needed to guide optimal therapy.<\/jats:p>","DOI":"10.1177\/2324709618788101","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:02:21Z","timestamp":1531990941000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Fatal Type B Lactic Acidosis Associated With Metastatic Colorectal Cancer: A Case Report With Review of Literature, Pathogenesis, and Treatment"],"prefix":"10.1177","volume":"6","author":[{"given":"Bharatsinh","family":"Gharia","sequence":"first","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karan","family":"Seegobin","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hetavi","family":"Mahida","sequence":"additional","affiliation":[{"name":"Jersey Shore University Medical Center, Neptune City, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"Shaikh","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevanne","family":"Matthews Hew","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dat","family":"Pham","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"bibr1-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-016-0267-8"},{"key":"bibr2-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002086."},{"key":"bibr3-2324709618788101","volume-title":"Cancer Facts and Figures 2017","author":"American Cancer Society","year":"2017"},{"key":"bibr4-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/476215."},{"key":"bibr5-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1100\/tsw.2011.125."},{"key":"bibr6-2324709618788101","unstructured":"National Cancer Institute. Cancer stat facts: colorectal cancer. https:\/\/seer.cancer.gov\/statfacts\/html\/colorect.html. Accessed June 27, 2018."},{"key":"bibr7-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-5002(98)00081-6"},{"key":"bibr8-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40701-3"},{"key":"bibr9-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyf050"},{"key":"bibr10-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200411000-00021"},{"key":"bibr11-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000223697.82390.b8"},{"key":"bibr12-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2011.03.020."},{"key":"bibr13-2324709618788101","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.82925."},{"key":"bibr14-2324709618788101","first-page":"120","volume":"69","author":"de Groot R","year":"2011","journal-title":"Neth J Med"},{"key":"bibr15-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2012.06.002."},{"key":"bibr16-2324709618788101","doi-asserted-by":"publisher","DOI":"10.4103\/1319-2442.144266"},{"key":"bibr17-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1159\/000430445."},{"key":"bibr18-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6148350."},{"key":"bibr19-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2289."},{"key":"bibr20-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-9-16."},{"key":"bibr21-2324709618788101","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.2.10205."},{"key":"bibr22-2324709618788101","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318125759a"},{"key":"bibr23-2324709618788101","unstructured":"National Comprehensive Cancer Network. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/colon.pdf. Accessed September 19, 2017."}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709618788101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709618788101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709618788101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:59:51Z","timestamp":1777449591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709618788101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":23,"alternative-id":["10.1177\/2324709618788101"],"URL":"https:\/\/doi.org\/10.1177\/2324709618788101","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2324709618788101"}}