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Her treatment with rituximab and bendamustine was discontinued when she developed disease progression after 3 cycles of therapy. She was then treated with obinutuzumab 1000 mg on day 1 of every cycle and chlorambucil 0.5 mg\/kg on days 1 and 15 every 28 days to which she had greater tolerability. After 4 cycles of treatment, she had resolution of her clinical symptoms, massive splenomegaly, and normalization of her white blood cell count.<\/jats:p>","DOI":"10.1177\/2324709618788674","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T10:12:46Z","timestamp":1531822366000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Novel Treatment With Obinutuzumab-Chlorambucil in a Patient With B-Cell Prolymphocytic Leukemia: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"6","author":[{"given":"Jason","family":"Hew","sequence":"first","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dat","family":"Pham","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevanne","family":"Matthews Hew","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Minocha","sequence":"additional","affiliation":[{"name":"University of Florida, Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"bibr1-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01069.x"},{"key":"bibr2-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-380139"},{"key":"bibr3-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014543271"},{"key":"bibr4-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2015.1.361.3917560"},{"key":"bibr5-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2015.12.002"},{"key":"bibr6-2324709618788674","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01245"},{"key":"bibr7-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.645.3798657"},{"key":"bibr8-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0541-5"},{"key":"bibr9-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01680.x"},{"key":"bibr10-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1080\/10428190400004521"},{"key":"bibr11-2324709618788674","first-page":"370","volume":"6","author":"Evans SS","year":"2015","journal-title":"J Adv Pract Oncol"},{"key":"bibr12-2324709618788674","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1313984."},{"key":"bibr13-2324709618788674","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.108552."}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709618788674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709618788674","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709618788674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:59:51Z","timestamp":1777449591000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709618788674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,1]]},"references-count":13,"alternative-id":["10.1177\/2324709618788674"],"URL":"https:\/\/doi.org\/10.1177\/2324709618788674","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,1]]},"article-number":"2324709618788674"}}