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Approximately 80% of cases are associated with kyphoscoliosis, which can be quite severe, as seen in our patient, causing paraplegia and restrictive lung disease. In this article, we present the third oldest documented male case of Coffin-Lowry syndrome with severe kyphoscoliosis, paraplegia, and restrictive lung disease.<\/jats:p>","DOI":"10.1177\/2324709618820660","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:57:19Z","timestamp":1547600239000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe Restrictive Lung Disease in One of the Oldest Documented Males With Coffin-Lowry Syndrome"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-634X","authenticated-orcid":false,"given":"Frederick","family":"Venter","sequence":"first","affiliation":[{"name":"Kern Medical Center, Bakersfield, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Evans","sequence":"additional","affiliation":[{"name":"Kern Medical Center, Bakersfield, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Fontes","sequence":"additional","affiliation":[{"name":"Kern Medical Center, Bakersfield, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Stewart","sequence":"additional","affiliation":[{"name":"Rio Bravo Family Medicine Residency Program, Bakersfield, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"bibr1-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.189"},{"key":"bibr2-2324709618820660","first-page":"205","volume":"112","author":"Coffin GS","year":"1966","journal-title":"Am J Dis Child"},{"key":"bibr3-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1971.02100170078009"},{"key":"bibr4-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80357-X"},{"key":"bibr5-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00723.x"},{"key":"bibr6-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1302\/1863-2548.12.170101"},{"key":"bibr7-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb02870.x"},{"key":"bibr8-2324709618820660","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200102)17:2<103::AID-HUMU2>3.0.CO;2-N"},{"key":"bibr9-2324709618820660","unstructured":"US National Library of Medicine. Coffin-Lowry syndrome. https:\/\/ghr.nlm.nih.gov\/condition\/coffin-lowry-syndrome#inheritance. 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