{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:35:03Z","timestamp":1777671303851,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Chronic lymphocytic leukemia (CLL) patients are at an increased risk for developing more aggressive lymphomas via Richter\u2019s transformation and of developing secondary malignancies. Despite the known association for secondary cancers, oropharyngeal cancers occur rarely. We present a case of a woman with a history of CLL who presented to our facility via transfer for impending airway compromise. Her initial workup was consistent with CLL; however, biopsies were taken of the neck mass because of its aggressive nature. She was treated with rituximab with good response. Final pathology showed evidence of CLL and tonsillar squamous cell carcinoma (SCC). Direct laryngoscopy and further biopsies yielded a diagnosis of unresectable oropharyngeal SCC. She was to be treated with chemotherapy and radiation for her SCC while holding treatment for CLL. This case demonstrates a rare and unexpected concurrent diagnosis.<\/jats:p>","DOI":"10.1177\/2324709619842904","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T02:24:55Z","timestamp":1555986295000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Concurrent Squamous Cell Carcinoma and Chronic Lymphocytic Leukemia Presenting as an Enlarging Neck Mass"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-2871","authenticated-orcid":false,"given":"Prabhjot","family":"Bhinder","sequence":"first","affiliation":[{"name":"University of Florida Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9371-0252","authenticated-orcid":false,"given":"Michael","family":"Chahin","sequence":"additional","affiliation":[{"name":"University of Florida Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Zuberi","sequence":"additional","affiliation":[{"name":"University of Florida Jacksonville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"bibr1-2324709619842904","unstructured":"Rai KR, Stilgenbauer S, Aster JC. Clinical features and diagnosis of chronic lymphocytic leukemia\/small lymphocytic lymphoma. https:\/\/www.uptodate.com\/contents\/clinical-features-and-diagnosis-of-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma. Accessed April 5, 2019."},{"key":"bibr2-2324709619842904","unstructured":"National Cancer Institute, Surveillance, Epidemiology, and End Results Program. Cancer Stat Facts: leukemia\u2014chronic lymphocytic leukemia (CLL). Bethesda, MD: National Cancer Institute. https:\/\/seer.cancer.gov\/statfacts\/html\/clyl.html. Accessed December 2, 2018."},{"key":"bibr3-2324709619842904","unstructured":"Rai KR, Stilgenbauer S. Staging and prognosis of chronic lymphocytic leukemia. https:\/\/www.uptodate.com\/contents\/staging-and-prognosis-of-chronic-lymphocytic-leukemia. Accessed April 5, 2019."},{"key":"bibr4-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5398"},{"key":"bibr5-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.5279.5279"},{"key":"bibr6-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-120123"},{"key":"bibr7-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2010.04.003"},{"key":"bibr8-2324709619842904","first-page":"8247353","volume":"2017","author":"Bersabe AR","year":"2017","journal-title":"Case Rep Oncol Med"},{"key":"bibr9-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2013.723"},{"key":"bibr10-2324709619842904","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21293"},{"key":"bibr11-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1080\/19338244.2015.1116429"},{"key":"bibr12-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-010-0228-9"},{"key":"bibr13-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq309"},{"key":"bibr14-2324709619842904","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2006.07.002"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709619842904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2324709619842904","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2324709619842904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:00:07Z","timestamp":1777449607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2324709619842904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":14,"alternative-id":["10.1177\/2324709619842904"],"URL":"https:\/\/doi.org\/10.1177\/2324709619842904","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"2324709619842904"}}