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We report the case of a 46-year-old male in whom the first sign of disseminated disease was increased skin pigmentation due to paraneoplastic Cushing\u2019s syndrome. He underwent 3 cycles of chemotherapy with carboplatin and paclitaxel with no symptomatic improvement and a mixed response on imaging. There is no evidence that systemic therapy prolongs survival in metastatic acinic cell carcinoma, and we lack a consensus as to which treatment options are most beneficial. A summary of published evidence regarding choice of palliative chemotherapy regimens and response is discussed in relation to the case.<\/jats:p>","DOI":"10.1177\/2324709620918080","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:48:50Z","timestamp":1589539730000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Ectopic ACTH Secretion Secondary to Metastatic Acinic Cell Carcinoma of the Parotid Gland: A Case Report and Review of Current Evidence for Systemic Therapy"],"prefix":"10.1177","volume":"8","author":[{"given":"Louise","family":"Wade","sequence":"first","affiliation":[{"name":"Royal United Hospitals Bath NHS Foundation Trust, Bath, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kitching","sequence":"additional","affiliation":[{"name":"Royal United Hospitals Bath NHS Foundation Trust, Bath, 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