{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:53Z","timestamp":1790660813842,"version":"4.1.0"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>To characterize the expression of steroidogenic enzymes implicated in the development of ovarian steroid cell tumors, not otherwise specified (SCT-NOS). We present 4 ovarian SCT-NOS evaluated by immunohistochemical staining of steroidogenic enzymes as an approach to define this entity pathologically. All 4 ovarian SCT-NOS showed increased expression for cholesterol side-chain cleavage enzyme (CYP11A1), 17\u03b1-hydroxylase (CYP17A1), 17\u03b2-hydroxysteroid dehydrogenase 1 (HSD17B1), aldo-ketoreductase type 1 C3 (AKR1C3), 3\u03b2-hydroxysteroid dehydrogenase 2 (HSD3B2), 5\u03b1-reductase type 2 (SRD5A2), steroid sulfatase (SULT2A1), estrogen sulfotransferase (EST), and aromatase (CYP19A1). Expression was negative for 21-hydroxylase (CYP21A2) and 17\u03b2-hydroxysteroid dehydrogenase 2 (HSD17B2). 17\u03b2-hydroxysteroid dehydrogenase 3 (HSD17B3) and 5\u03b1-reductase type 1 (SRD5A1) showed variable expression. Our analysis reveals a novel finding of increased expression of AKR1C3, HSD17B1, SRD5A2, SULT2A1, and EST in ovarian SCT-NOS, which is clinically associated with androgen excess and virilization. Further studies are needed to validate these enzymes as new markers in the evaluation of hyperandrogenic ovarian conditions.<\/jats:p>","DOI":"10.1177\/2324709620933416","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T01:49:17Z","timestamp":1593222557000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of Key Androgen-Activating Enzymes in Ovarian Steroid Cell Tumor, Not Otherwise Specified"],"prefix":"10.1177","volume":"8","author":[{"given":"Evana","family":"Valenzuela Scheker","sequence":"first","affiliation":[{"name":"Memorial Healthcare System Hollywood, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Kathuria","sequence":"additional","affiliation":[{"name":"University of Central Florida, Orlando, FL, 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