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Adverse effects of nitrofurantoin are generally considered mild, with gastrointestinal complaints being the most common. However, there have been isolated case reports describing a more severe systemic inflammatory response syndrome\u2013like reaction, which leads to diagnostic challenges and treatment complications. We report the case of a patient with repeat episodes of systemic inflammatory response syndrome secondary to nitrofurantoin, which was initially attributed to recurrent urinary tract infections.<\/jats:p>","DOI":"10.1177\/2324709620984610","type":"journal-article","created":{"date-parts":[[2021,2,13]],"date-time":"2021-02-13T07:10:38Z","timestamp":1613200238000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic Inflammatory Response Syndrome Secondary to Nitrofurantoin"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-9222","authenticated-orcid":false,"given":"Molly R.","family":"McGarry","sequence":"first","affiliation":[{"name":"Memphis VA Medical Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith W.","family":"Wagner","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry M.","family":"Wall","sequence":"additional","affiliation":[{"name":"Memphis VA Medical Center, Memphis, TN, USA"},{"name":"University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,13]]},"reference":[{"key":"bibr1-2324709620984610","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq257"},{"key":"bibr2-2324709620984610","unstructured":"Nitrofurantoin. 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