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We report a case of a 54-year-old male with new-onset seizure who tested positive for severe acute respiratory syndrome coronavirus 2 from a nasopharyngeal swab sample. Investigative findings, which included contrast-enhancing right posterior temporal lobe T2-hyperintensity on brain magnetic resonance imaging, right-sided lateralized periodic discharges on the electroencephalogram, and elevated protein level on cerebrospinal fluid analysis, supported the diagnosis of possible encephalitis from COVID-19 infection. The findings in this case are placed in the context of the existing literature.<\/jats:p>","DOI":"10.1177\/2324709620986302","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T22:45:53Z","timestamp":1614638753000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["New-Onset Seizure With Possible Limbic Encephalitis in a Patient With COVID-19 Infection: A Case Report and Review"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-3665","authenticated-orcid":false,"given":"Riwaj","family":"Bhagat","sequence":"first","affiliation":[{"name":"University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kwiecinska","sequence":"additional","affiliation":[{"name":"University of Louisville, Louisville, KY, 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