{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:39:19Z","timestamp":1777671559002,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>A 40-year-old male with a right-sided neck mass was diagnosed with metastatic melanoma. A repeat positron-emission tomography after treatment with combination immunotherapy demonstrated increased hypermetabolic activity in the right supraclavicular, hilar, and mediastinal regions. Immunotherapy was discontinued and a BRAF\/MEK inhibitor combination was started. Repeat imaging showed a decrease in size of the neck mass; however, hilar and mediastinal lymph nodes increased in size. A fine needle aspiration of mediastinal lymph nodes was consistent with a granulomatous process. A diagnosis of a sarcoid-like reaction (SLR) was made, and he was started on steroids. A follow-up positron emission tomography showed decreased hilar and mediastinal lymph node hypermetabolic activity. We, therefore, report this rare case of immunotherapy-induced SLR to the expanding literature on immunotherapy-related adverse effects and would like to highlight that SLR can occur in conjunction with disease progression making it challenging to distinguish between the two.<\/jats:p>","DOI":"10.1177\/23247096211009400","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T09:52:40Z","timestamp":1618307560000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunotherapy-Induced Sarcoid-Like Reaction: A Shrewd Imitator"],"prefix":"10.1177","volume":"9","author":[{"given":"Hassaan","family":"Yasin","sequence":"first","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Yadala","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noman Ahmed Jang","family":"Khan","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Graffeo","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Denning","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Lebowicz","sequence":"additional","affiliation":[{"name":"Marshall University, Huntington, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"bibr1-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2010.09.003"},{"key":"bibr2-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0779-6"},{"key":"bibr3-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0323-0"},{"key":"bibr4-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000437"},{"key":"bibr5-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0715"},{"key":"bibr6-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.031"},{"key":"bibr7-23247096211009400","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141121463"},{"key":"bibr8-23247096211009400","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0128"},{"key":"bibr9-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071714"},{"key":"bibr10-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9826-3"},{"key":"bibr11-23247096211009400","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw125"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096211009400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096211009400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096211009400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:01:06Z","timestamp":1777449666000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096211009400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":11,"alternative-id":["10.1177\/23247096211009400"],"URL":"https:\/\/doi.org\/10.1177\/23247096211009400","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"article-number":"23247096211009400"}}