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Radiological and serological testing led to a diagnosis of acute hypoxic miliary coccidioidomycosis. A 52-year-old man with a past medical history of chronic kidney disease (CKD) was treated with prednisone for focal segmental glomerulosclerosis (FSGS). Within 2 weeks, this patient developed bilateral lower extremity weakness. Radiology, serology, and lumbar puncture proved a diagnosis of reactivated coccidioidomycosis with miliary pattern and coccidioidomycosis meningoencephalitis with arachnoiditis. Whether treatment with glucocorticoids caused reactivation of coccidioidomycosis is discussed in this case series.<\/jats:p>","DOI":"10.1177\/23247096211051928","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T07:07:17Z","timestamp":1646032037000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Two Cases of Miliary and Disseminated Coccidioidomycosis Following Glucocorticoid Therapy and Literature Review"],"prefix":"10.1177","volume":"10","author":[{"given":"Rowis","family":"Sous","sequence":"first","affiliation":[{"name":"Kern Medical, Bakersfield, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuliya","family":"Levkiavska","sequence":"additional","affiliation":[{"name":"Kern Medical, Bakersfield, CA, 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