{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:45:08Z","timestamp":1777671908406,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Medicine High Impact Case Reports"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Risk factors for infective endocarditis (IE) include congenital heart defects, poor dentition, immunosuppression, or recent instrumentation. The occupational hazard of a dog bite, combined with bicuspid aortic valve (BAV) led to IE. 16S ribosomal DNA was able to pinpoint the causative organism. A healthy 33-year-old postman presented in profound heart failure and sepsis due to aortic regurgitation and an aortic root abscess. He underwent emergency aortic valve replacement and was found to have a BAV and anomalous right coronary artery. Blood cultures remained negative. 16S ribosomal DNA polymerase chain reaction (PCR) revealed the causative organism was Capnocytophaga canimorsus. On review, he recalled receiving a dog bite followed by a febrile illness a few days later. Congenital BAVs may become infected by seemingly innocuous injuries. 16S rDNA PCR is a more sensitive and specific diagnostic test than culture. This case demonstrates its utility in providing appropriate antimicrobial management for IE.<\/jats:p>","DOI":"10.1177\/23247096221092283","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T02:47:47Z","timestamp":1653965267000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["An Infected Bicuspid Aortic Valve, an Anomalous Coronary Artery, and a Dog-Bitten Postman"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0523-5223","authenticated-orcid":false,"given":"Marliza","family":"O\u2019Dwyer","sequence":"first","affiliation":[{"name":"St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie-Anne","family":"Houlihan","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhbh","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Young","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"St James\u2019s Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"bibr1-23247096221092283","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2019.10.05"},{"key":"bibr2-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.10.027"},{"key":"bibr3-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2010.01116.x"},{"key":"bibr4-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.618082"},{"key":"bibr5-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.921106"},{"issue":"23","key":"bibr6-23247096221092283","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2008.10.002","volume":"52","author":"Warnes CA","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"key":"bibr7-23247096221092283","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.85a.17069"},{"key":"bibr8-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70076-5"},{"key":"bibr9-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000331"},{"key":"bibr10-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4492-3"},{"key":"bibr11-23247096221092283","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2007.02.005"}],"container-title":["Journal of Investigative Medicine High Impact Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096221092283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23247096221092283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23247096221092283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:02:45Z","timestamp":1777449765000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23247096221092283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":11,"alternative-id":["10.1177\/23247096221092283"],"URL":"https:\/\/doi.org\/10.1177\/23247096221092283","relation":{},"ISSN":["2324-7096","2324-7096"],"issn-type":[{"value":"2324-7096","type":"print"},{"value":"2324-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"23247096221092283"}}